Gene description for RASA4
Gene name RAS p21 protein activator 4
Gene symbol RASA4
Other names/aliases CAPRI
GAPL
Species Homo sapiens
 Database cross references - RASA4
ExoCarta ExoCarta_10156
Vesiclepedia VP_10156
Entrez Gene 10156
HGNC 23181
MIM 607943
UniProt O43374  
 RASA4 identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for RASA4
Molecular Function
    GTPase activator activity GO:0005096 IDA
    phospholipid binding GO:0005543 IEA
    metal ion binding GO:0046872 IEA
Biological Process
    negative regulation of GTPase activity GO:0034260 IDA
    negative regulation of GTPase activity GO:0034260 IMP
    intracellular signal transduction GO:0035556 IEA
    negative regulation of Ras protein signal transduction GO:0046580 IEA
    cellular response to calcium ion GO:0071277 IMP
Subcellular Localization
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IDA
 Experiment description of studies that identified RASA4 in sEVs
1
Experiment ID 126
MISEV standards
✘ Biophysical techniques
✔
GAPDH
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for RASA4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CLK4  
Affinity Capture-MS Homo sapiens
2 HRAS 3265
Reconstituted Complex Homo sapiens
3 NTRK1 4914
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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