Gene description for Slc6a8
Gene name solute carrier family 6 (neurotransmitter transporter, creatine), member 8
Gene symbol Slc6a8
Other names/aliases AA589632
CRT
CRTR
CT1
CTR5
Creat
Species Mus musculus
 Database cross references - Slc6a8
ExoCarta ExoCarta_102857
Vesiclepedia VP_102857
Entrez Gene 102857
UniProt Q8VBW1  
 Slc6a8 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Slc6a8
Molecular Function
    creatine transmembrane transporter activity GO:0005308 ISO
    creatine transmembrane transporter activity GO:0005308 ISS
    creatine:sodium symporter activity GO:0005309 IDA
    creatine:sodium symporter activity GO:0005309 ISO
    gamma-aminobutyric acid:sodium:chloride symporter activity GO:0005332 IBA
    choline transmembrane transporter activity GO:0015220 ISO
Biological Process
    sodium ion transport GO:0006814 IEA
    neurotransmitter transport GO:0006836 IEA
    amino acid transport GO:0006865 IBA
    creatine transmembrane transport GO:0015881 ISO
    creatine transmembrane transport GO:0015881 ISS
    creatine transmembrane transport GO:0015881 ISS
    protein catabolic process GO:0030163 ISO
    sodium ion transmembrane transport GO:0035725 IBA
    nitrogen compound transport GO:0071705 ISO
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 ISO
    apical plasma membrane GO:0016324 IEA
    apical plasma membrane GO:0016324 ISO
    synapse GO:0045202 ISO
    postsynaptic membrane GO:0045211 ISO
    glutamatergic synapse GO:0098978 ISO
 Experiment description of studies that identified Slc6a8 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Slc6a8
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PPIL3 53938
Affinity Capture-MS Homo sapiens
2 SSR3 6747
Affinity Capture-MS Homo sapiens
3 MAPT  
Affinity Capture-MS Homo sapiens
4 MAGED2 10916
Affinity Capture-MS Homo sapiens
5 Usp7  
Affinity Capture-MS Mus musculus
6 SCYL1 57410
Affinity Capture-MS Homo sapiens
7 ELOVL5 60481
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which Slc6a8 is involved
PathwayEvidenceSource
Creatine metabolism IEA Reactome
Metabolism IEA Reactome
Metabolism of amino acids and derivatives IEA Reactome





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