Gene description for Slc6a8
Gene name solute carrier family 6 (neurotransmitter transporter, creatine), member 8
Gene symbol Slc6a8
Other names/aliases AA589632
CRT
CRTR
CT1
CTR5
Creat
Species Mus musculus
 Database cross references - Slc6a8
ExoCarta ExoCarta_102857
Vesiclepedia VP_102857
Entrez Gene 102857
UniProt Q8VBW1  
 Slc6a8 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Slc6a8
Molecular Function
    creatine transmembrane transporter activity GO:0005308 ISS
    creatine:sodium symporter activity GO:0005309 ISO
    neurotransmitter:sodium symporter activity GO:0005328 IEA
    choline transmembrane transporter activity GO:0015220 ISO
    symporter activity GO:0015293 IEA
Biological Process
    creatine transmembrane transport GO:1902598 ISS
    organic cation transport GO:0015695 ISO
    cofactor transport GO:0051181 ISS
    neurotransmitter transport GO:0006836 IEA
    choline transport GO:0015871 ISO
    transport GO:0006810 IEA
    sodium ion transport GO:0006814 IEA
    ion transport GO:0006811 IEA
    sodium ion transmembrane transport GO:0035725 ISO
    ammonium transmembrane transport GO:0072488 ISO
    creatine transport GO:0015881 ISS
Subcellular Localization
    membrane GO:0016020 IEA
    integral component of membrane GO:0016021 IEA
    integral component of plasma membrane GO:0005887 IEA
 Experiment description of studies that identified Slc6a8 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Slc6a8
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Slc6a8 is involved
PathwayEvidenceSource
Creatine metabolism IEA Reactome





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