Gene description for Yars
Gene name tyrosyl-tRNA synthetase
Gene symbol Yars
Other names/aliases AL024047
AU018965
Species Mus musculus
 Database cross references - Yars
ExoCarta ExoCarta_107271
Vesiclepedia VP_107271
Entrez Gene 107271
UniProt Q91WQ3  
 Yars identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Yars
Molecular Function
    tRNA binding GO:0000049 IEA
    tyrosine-tRNA ligase activity GO:0004831 IBA
    tyrosine-tRNA ligase activity GO:0004831 ISO
    tyrosine-tRNA ligase activity GO:0004831 ISS
    ATP binding GO:0005524 IEA
    small molecule binding GO:0036094 ISO
    small molecule binding GO:0036094 ISS
Biological Process
    tyrosyl-tRNA aminoacylation GO:0006437 IEA
    tyrosyl-tRNA aminoacylation GO:0006437 ISO
    response to starvation GO:0042594 IEA
    response to starvation GO:0042594 ISO
Subcellular Localization
    nucleus GO:0005634 ISO
    nucleus GO:0005634 ISS
    cytoplasm GO:0005737 ISO
    cytosol GO:0005829 ISO
    cytosol GO:0005829 ISO
    cytosol GO:0005829 ISS
    nuclear body GO:0016604 IEA
    nuclear body GO:0016604 ISO
 Experiment description of studies that identified Yars in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Yars
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Atxn1  
Proximity Label-MS Mus musculus
Affinity Capture-MS Mus musculus
2 Ddx39 68278
Two-hybrid Mus musculus
3 Kctd13  
Affinity Capture-MS Mus musculus
4 CPSF7 79869
Two-hybrid Homo sapiens
5 Nphp4  
Affinity Capture-MS Mus musculus
View the network image/svg+xml
 Pathways in which Yars is involved
No pathways found





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