Experiment description of studies that identified ADAM28 in sEVs

1 Experiment ID 622 MISEV standards ✔ EM Biophysical techniques Enriched markers ✔ GOLGA2|CYC1 Negative markers ✔ NTA Particle analysis Identified molecule Protein Identification method Mass spectrometry PubMed ID 29339034     Organism Homo sapiens Experiment description Extracellular matrix proteins and carcinoembryonic antigen-related cell adhesion molecules characterize pancreatic duct fluid exosomes in patients with pancreatic cancer Authors "Zheng J, Hernandez JM, Doussot A, Bojmar L, Zambirinis CP, Costa-Silva B, van Beek EJAH, Mark MT, Molina H, Askan G, Basturk O, Gonen M, Kingham TP, Allen PJ, D'Angelica MI, DeMatteo RP, Lyden D, Jarnagin WR." Journal name HPB Publication year 2018 Sample Pancreatic duct fluid Sample name From patients with Pancreatic ductal adenocarcinoma Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry

2 Experiment ID 623 MISEV standards ✘ Biophysical techniques Enriched markers ✔ GOLGA2|CYC1 Negative markers ✔ NTA Particle analysis Identified molecule Protein Identification method Mass spectrometry PubMed ID 29339034     Organism Homo sapiens Experiment description Extracellular matrix proteins and carcinoembryonic antigen-related cell adhesion molecules characterize pancreatic duct fluid exosomes in patients with pancreatic cancer Authors "Zheng J, Hernandez JM, Doussot A, Bojmar L, Zambirinis CP, Costa-Silva B, van Beek EJAH, Mark MT, Molina H, Askan G, Basturk O, Gonen M, Kingham TP, Allen PJ, D'Angelica MI, DeMatteo RP, Lyden D, Jarnagin WR." Journal name HPB Publication year 2018 Sample Pancreatic duct fluid Sample name From patients with IPMN with microinvasive cancer (IPMNca) Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry

3 Experiment ID 625 MISEV standards ✘ Biophysical techniques Enriched markers ✔ GOLGA2|CYC1 Negative markers ✔ NTA Particle analysis Identified molecule Protein Identification method Mass spectrometry PubMed ID 29339034     Organism Homo sapiens Experiment description Extracellular matrix proteins and carcinoembryonic antigen-related cell adhesion molecules characterize pancreatic duct fluid exosomes in patients with pancreatic cancer Authors "Zheng J, Hernandez JM, Doussot A, Bojmar L, Zambirinis CP, Costa-Silva B, van Beek EJAH, Mark MT, Molina H, Askan G, Basturk O, Gonen M, Kingham TP, Allen PJ, D'Angelica MI, DeMatteo RP, Lyden D, Jarnagin WR." Journal name HPB Publication year 2018 Sample Pancreatic duct fluid Sample name From patients with benign pancreatic disease Isolation/purification methods Differential centrifugation Ultracentrifugation Flotation density - Molecules identified in the study Protein Methods used in the study Mass spectrometry

Protein-protein interactions for ADAM28

Protein Interactor ExoCarta ID Identification method PubMed Species 1 TP53 7157 Synthetic Growth Defect Homo sapiens 2 RPA3 6119 Proximity Label-MS Homo sapiens View the network

Pathways in which ADAM28 is involved

No pathways found