Gene description for Fdps
Gene name farnesyl diphosphate synthetase
Gene symbol Fdps
Other names/aliases 6030492I17Rik
AI256750
Fdpsl1
mKIAA1293
Species Mus musculus
 Database cross references - Fdps
ExoCarta ExoCarta_110196
Entrez Gene 110196
UniProt Q920E5  
 Fdps identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
Mov neuroglial cells 15210972    
 Gene ontology annotations for Fdps
Molecular Function
    dimethylallyltranstransferase activity GO:0004161 IEA
    transferase activity GO:0016740 IEA
    geranyltranstransferase activity GO:0004337 ISO
    poly(A) RNA binding GO:0044822 ISO
    metal ion binding GO:0046872 IEA
    farnesyltranstransferase activity GO:0004311 ISO
Biological Process
    sterol biosynthetic process GO:0016126 IEA
    cholesterol metabolic process GO:0008203 IEA
    isoprenoid biosynthetic process GO:0008299 ISO
    cholesterol biosynthetic process GO:0006695 IEA
    farnesyl diphosphate biosynthetic process GO:0045337 ISO
    positive regulation of cholesterol biosynthetic process GO:0045542 ISO
    lipid metabolic process GO:0006629 IEA
    steroid metabolic process GO:0008202 IEA
    positive regulation of cell growth involved in cardiac muscle cell development GO:0061051 ISO
    steroid biosynthetic process GO:0006694 IEA
Subcellular Localization
    cytoplasm GO:0005737 ISO
    mitochondrial matrix GO:0005759 ISO
    nucleoplasm GO:0005654 ISO
    mitochondrion GO:0005739 IDA
    peroxisome GO:0005777 ISO
 Experiment description of studies that identified Fdps in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
2
Experiment ID 39
ISEV standards
✔
IEM
EV Biophysical techniques
✔
TSG101|HSC70
EV Cytosolic markers
✔
FLOT1
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 15210972    
Organism Mus musculus
Experiment description Cells release prions in association with exosomes.
Authors Fevrier B, Vilette D, Archer F, Loew D, Faigle W, Vidal M, Laude H, Raposo G
Journal name PNAS
Publication year 2004
Sample Mov neuroglial cells
Sample name Mov neuroglial cell
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QSTAR]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for Fdps
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Fdps is involved
PathwayEvidenceSource
Activation of gene expression by SREBF (SREBP) IEA Reactome
Cholesterol biosynthesis IEA Reactome





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