Gene description for Aacs
Gene name acetoacetyl-CoA synthetase
Gene symbol Aacs
Other names/aliases 2210408B16Rik
SUR5
Species Mus musculus
 Database cross references - Aacs
ExoCarta ExoCarta_78894
Vesiclepedia VP_78894
Entrez Gene 78894
UniProt Q9D2R0  
 Aacs identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Aacs
Molecular Function
    nucleotide binding GO:0000166 IEA
    ligase activity GO:0016874 IEA
    acetoacetate-CoA ligase activity GO:0030729 ISO
    ATP binding GO:0005524 IEA
    catalytic activity GO:0003824 IEA
    butyrate-CoA ligase activity GO:0047760 ISO
Biological Process
    fatty acid metabolic process GO:0006631 IEA
    positive regulation of insulin secretion GO:0032024 ISO
    response to organic cyclic compound GO:0014070 ISO
    lipid metabolic process GO:0006629 IEA
    liver development GO:0001889 ISO
    response to ethanol GO:0045471 ISO
    metabolic process GO:0008152 IEA
    cellular response to glucose stimulus GO:0071333 ISO
    response to organonitrogen compound GO:0010243 ISO
    response to oleic acid GO:0034201 ISO
    response to nutrient GO:0007584 ISO
    response to drug GO:0042493 ISO
Subcellular Localization
    cytoplasm GO:0005737 IEA
    cytosol GO:0005829 ISO
 Experiment description of studies that identified Aacs in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Aacs
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Aacs is involved
No pathways found





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