Gene description for IL1RAPL1
Gene name interleukin 1 receptor accessory protein-like 1
Gene symbol IL1RAPL1
Other names/aliases IL1R8
IL1RAPL
MRX10
MRX21
MRX34
OPHN4
TIGIRR-2
Species Homo sapiens
 Database cross references - IL1RAPL1
ExoCarta ExoCarta_11141
Entrez Gene 11141
HGNC 5996
MIM 300206
UniProt Q9NZN1  
 IL1RAPL1 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for IL1RAPL1
Molecular Function
    voltage-gated calcium channel activity GO:0005245 ISS
    interleukin-1 binding GO:0019966 IDA
    protein binding GO:0005515 IPI
    receptor binding GO:0005102 ISS
Biological Process
    negative regulation of exocytosis GO:0045920 IDA
    heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 ISS
    calcium ion transmembrane transport GO:0070588 ISS
    neuron differentiation GO:0030182 ISS
    positive regulation of dendrite morphogenesis GO:0050775 ISS
    signal transduction GO:0007165 IEA
    presynaptic membrane assembly GO:0097105 ISS
    regulation of neuron projection development GO:0010975 ISS
Subcellular Localization
    axon GO:0030424 IEA
    postsynaptic membrane GO:0045211 NAS
    cytoplasm GO:0005737 IEA
    cell surface GO:0009986 ISS
    dendrite GO:0030425 ISS
    plasma membrane GO:0005886 IDA
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified IL1RAPL1 in exosomes
1
Experiment ID 126
ISEV standards
✘ EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for IL1RAPL1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NCS1 23413
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which IL1RAPL1 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here