Gene description for NUDT4 |
Gene name |
nudix (nucleoside diphosphate linked moiety X)-type motif 4 |
Gene symbol |
NUDT4 |
Other names/aliases |
DIPP2 DIPP2alpha DIPP2beta HDCMB47P |
Species |
Homo sapiens |
Database cross references - NUDT4 |
ExoCarta |
ExoCarta_11163 |
Entrez Gene |
11163 |
HGNC |
8051 |
MIM |
609229 |
UniProt |
Q9NZJ9
|
NUDT4 identified in exosomes derived from the following tissue/cell type |
Thymus
|
23844026
|
Gene ontology annotations for NUDT4 |
Molecular Function |
|
inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity |
GO:0052846 |
IEA |
|
|
metal ion binding |
GO:0046872 |
IEA |
|
|
inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity |
GO:0052848 |
IEA |
|
|
inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity |
GO:0052845 |
IEA |
|
|
inositol diphosphate tetrakisphosphate diphosphatase activity |
GO:0052840 |
TAS |
|
|
inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity |
GO:0052847 |
IEA |
|
|
m7G(5')pppN diphosphatase activity |
GO:0050072 |
ISS |
|
|
inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity |
GO:0052843 |
IEA |
|
|
snoRNA binding |
GO:0030515 |
ISS |
|
|
inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity |
GO:0052844 |
IEA |
|
|
diphosphoinositol-polyphosphate diphosphatase activity |
GO:0008486 |
IDA |
|
|
protein binding |
GO:0005515 |
IPI |
|
Biological Process |
|
inositol phosphate metabolic process |
GO:0043647 |
TAS |
|
|
calcium-mediated signaling |
GO:0019722 |
TAS |
|
|
small molecule metabolic process |
GO:0044281 |
TAS |
|
|
cyclic nucleotide metabolic process |
GO:0009187 |
TAS |
|
|
cyclic-nucleotide-mediated signaling |
GO:0019935 |
TAS |
|
|
intracellular signal transduction |
GO:0035556 |
NAS |
|
|
regulation of RNA export from nucleus |
GO:0046831 |
TAS |
|
|
intracellular transport |
GO:0046907 |
TAS |
|
Subcellular Localization |
|
cytosol |
GO:0005829 |
TAS |
|
|
intracellular |
GO:0005622 |
TAS |
|
|
Experiment description of studies that identified NUDT4 in exosomes |
1 |
Experiment ID |
217 |
ISEV standards |
✔
EM
|
EV Biophysical techniques |
✔
TSG101
|
EV Cytosolic markers |
✔
CD81|CD9|CD63
|
EV Membrane markers |
✘
|
EV Negative markers |
✔
NTA
|
EV Particle analysis
|
|
Identified molecule |
protein
|
Identification method |
Mass spectrometry
|
PubMed ID |
23844026
|
Organism |
Homo sapiens |
Experiment description |
Characterization of human thymic exosomes. |
Authors |
Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O. |
Journal name |
PLoS One
|
Publication year |
2013 |
Sample |
Thymus |
Sample name |
Normal-Thymus |
Isolation/purification methods |
Differential centrifugation Filtration Ultracentrifugation |
Flotation density |
-
|
Molecules identified in the study |
Protein |
Methods used in the study |
Mass spectrometry |
|
|
Protein-protein interactions for NUDT4 |
|
Protein Interactor |
ExoCarta ID |
Identification method |
PubMed |
Species |
No interactions are found.
|
|
Pathways in which NUDT4 is involved |
|
|
|