Gene description for NUDT4
Gene name nudix (nucleoside diphosphate linked moiety X)-type motif 4
Gene symbol NUDT4
Other names/aliases DIPP2
DIPP2alpha
DIPP2beta
HDCMB47P
Species Homo sapiens
 Database cross references - NUDT4
ExoCarta ExoCarta_11163
Entrez Gene 11163
HGNC 8051
MIM 609229
UniProt Q9NZJ9  
 NUDT4 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for NUDT4
Molecular Function
    inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity GO:0052846 IEA
    metal ion binding GO:0046872 IEA
    inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity GO:0052848 IEA
    inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity GO:0052845 IEA
    inositol diphosphate tetrakisphosphate diphosphatase activity GO:0052840 TAS
    inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity GO:0052847 IEA
    m7G(5')pppN diphosphatase activity GO:0050072 ISS
    inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity GO:0052843 IEA
    snoRNA binding GO:0030515 ISS
    inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity GO:0052844 IEA
    diphosphoinositol-polyphosphate diphosphatase activity GO:0008486 IDA
    protein binding GO:0005515 IPI
Biological Process
    inositol phosphate metabolic process GO:0043647 TAS
    calcium-mediated signaling GO:0019722 TAS
    small molecule metabolic process GO:0044281 TAS
    cyclic nucleotide metabolic process GO:0009187 TAS
    cyclic-nucleotide-mediated signaling GO:0019935 TAS
    intracellular signal transduction GO:0035556 NAS
    regulation of RNA export from nucleus GO:0046831 TAS
    intracellular transport GO:0046907 TAS
Subcellular Localization
    cytosol GO:0005829 TAS
    intracellular GO:0005622 TAS
 Experiment description of studies that identified NUDT4 in exosomes
1
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for NUDT4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which NUDT4 is involved
PathwayEvidenceSource
Synthesis of pyrophosphates in the cytosol TAS Reactome





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