Gene description for ELFN2
Gene name extracellular leucine-rich repeat and fibronectin type III domain containing 2
Gene symbol ELFN2
Other names/aliases LRRC62
PPP1R29
Species Homo sapiens
 Database cross references - ELFN2
ExoCarta ExoCarta_114794
Vesiclepedia VP_114794
Entrez Gene 114794
HGNC 29396
UniProt Q5R3F8  
 ELFN2 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for ELFN2
Molecular Function
    protein phosphatase inhibitor activity GO:0004864 IEA
Biological Process
    synaptic membrane adhesion GO:0099560 IEA
Subcellular Localization
    extracellular space GO:0005615 HDA
    extracellular space GO:0005615 IBA
    extracellular matrix GO:0031012 IBA
    postsynaptic density membrane GO:0098839 IEA
 Experiment description of studies that identified ELFN2 in exosomes
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for ELFN2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HNRNPH1 3187
Affinity Capture-RNA Homo sapiens
2 UBR4 23352
Affinity Capture-MS Homo sapiens
3 KCMF1 56888
Affinity Capture-MS Homo sapiens
4 CALM3 808
Affinity Capture-MS Homo sapiens
5 DPP9 91039
Affinity Capture-MS Homo sapiens
6 RAB11FIP4  
Affinity Capture-MS Homo sapiens
7 CDH1 999
Proximity Label-MS Homo sapiens
8 ACAD11 84129
Affinity Capture-MS Homo sapiens
9 ELFN1  
Affinity Capture-MS Homo sapiens
10 INSIG2  
Affinity Capture-MS Homo sapiens
11 CTDSPL2  
Affinity Capture-MS Homo sapiens
12 PDF  
Affinity Capture-MS Homo sapiens
13 TBC1D1 23216
Affinity Capture-MS Homo sapiens
14 TBC1D4  
Affinity Capture-MS Homo sapiens
15 TUBB1 81027
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ELFN2 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here