Gene description for ELFN2
Gene name extracellular leucine-rich repeat and fibronectin type III domain containing 2
Gene symbol ELFN2
Other names/aliases LRRC62
Species Homo sapiens
 Database cross references - ELFN2
ExoCarta ExoCarta_114794
Entrez Gene 114794
HGNC 29396
UniProt Q5R3F8  
 ELFN2 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for ELFN2
Molecular Function
    phosphatase binding GO:0019902 IDA
    protein phosphatase inhibitor activity GO:0004864 IEA
Biological Process
    negative regulation of phosphatase activity GO:0010923 IDA
Subcellular Localization
    integral component of membrane GO:0016021 IEA
    extracellular space GO:0005615 IDA
 Experiment description of studies that identified ELFN2 in exosomes
Experiment ID 237
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for ELFN2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ELFN2 is involved
No pathways found

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