Gene description for Casp6
Gene name	caspase 6
Gene symbol	Casp6
Other names/aliases	CASP-6 Mch2
Species	Mus musculus
Database cross references - Casp6
ExoCarta	ExoCarta_12368
Vesiclepedia	VP_12368
Entrez Gene	12368
UniProt	O08738
Casp6 identified in sEVs derived from the following tissue/cell type
Mast cells	17486113

Gene ontology annotations for Casp6

Molecular Function     endopeptidase activity GO:0004175 IDA     endopeptidase activity GO:0004175 ISO     cysteine-type endopeptidase activity GO:0004197 IBA     cysteine-type endopeptidase activity GO:0004197 ISO     cysteine-type endopeptidase activity GO:0004197 ISS     protein binding GO:0005515 IPI     peptidase activity GO:0008233 RCA     identical protein binding GO:0042802 IEA     identical protein binding GO:0042802 ISO Biological Process     activation of innate immune response GO:0002218 ISO     activation of innate immune response GO:0002218 ISS     acute inflammatory response to non-antigenic stimulus GO:0002525 ISO     proteolysis GO:0006508 ISO     proteolysis GO:0006508 RCA     apoptotic process GO:0006915 IBA     axonal fasciculation GO:0007413 ISO     response to glucose GO:0009749 ISO     response to iron ion GO:0010039 ISO     protein autoprocessing GO:0016540 ISO     protein autoprocessing GO:0016540 ISS     epithelial cell differentiation GO:0030855 IEA     response to cytokine GO:0034097 ISO     response to hydrogen peroxide GO:0042542 ISO     regulation of apoptotic process GO:0042981 RCA     positive regulation of apoptotic process GO:0043065 ISO     positive regulation of apoptotic process GO:0043065 ISS     regulation of programmed cell death GO:0043067 ISO     positive regulation of neuron apoptotic process GO:0043525 IBA     positive regulation of neuron apoptotic process GO:0043525 ISO     positive regulation of retinal cell programmed cell death GO:0046670 ISO     positive regulation of necroptotic process GO:0060545 ISO     positive regulation of necroptotic process GO:0060545 ISS     pyroptotic inflammatory response GO:0070269 ISO     pyroptotic inflammatory response GO:0070269 ISS     intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 ISO     intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 ISS     cellular response to staurosporine GO:0072734 IEA     cellular response to staurosporine GO:0072734 ISO     hepatocyte apoptotic process GO:0097284 ISO     hepatocyte apoptotic process GO:0097284 ISS Subcellular Localization     nucleus GO:0005634 ISO     nucleus GO:0005634 ISS     nucleoplasm GO:0005654 IEA     nucleoplasm GO:0005654 ISO     cytoplasm GO:0005737 IBA     cytoplasm GO:0005737 ISO     cytoplasm GO:0005737 ISS     cytosol GO:0005829 IEA     cytosol GO:0005829 ISO     axon GO:0030424 ISO     neuronal cell body GO:0043025 ISO