Gene description for Casp6
Gene name caspase 6
Gene symbol Casp6
Other names/aliases CASP-6
Mch2
Species Mus musculus
 Database cross references - Casp6
ExoCarta ExoCarta_12368
Entrez Gene 12368
UniProt O08738  
 Casp6 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Casp6
Molecular Function
    cysteine-type endopeptidase activity involved in execution phase of apoptosis GO:0097200 IBA
    peptidase activity GO:0008233 RCA
    cysteine-type peptidase activity GO:0008234 IEA
    endopeptidase activity GO:0004175 ISO
    cysteine-type endopeptidase activity GO:0004197 IEA
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 ISO
    hydrolase activity GO:0016787 IEA
Biological Process
    response to iron ion GO:0010039 ISO
    response to hydrogen peroxide GO:0042542 ISO
    response to cytokine GO:0034097 ISO
    positive regulation of neuron apoptotic process GO:0043525 ISO
    proteolysis GO:0006508 RCA
    acute inflammatory response to non-antigenic stimulus GO:0002525 ISO
    regulation of apoptotic process GO:0042981 RCA
    apoptotic process GO:0006915 IBA
    response to glucose GO:0009749 ISO
    positive regulation of apoptotic process GO:0043065 ISO
    execution phase of apoptosis GO:0097194 IBA
    positive regulation of retinal cell programmed cell death GO:0046670 ISO
Subcellular Localization
    nucleus GO:0005634 ISO
    cytosol GO:0005829 ISO
    nucleoplasm GO:0005654 ISO
    cytoplasm GO:0005737 ISO
 Experiment description of studies that identified Casp6 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Casp6
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here