Gene description for PACRG
Gene name PARK2 co-regulated
Gene symbol PACRG
Other names/aliases GLUP
HAK005771
PARK2CRG
Species Homo sapiens
 Database cross references - PACRG
ExoCarta ExoCarta_135138
Vesiclepedia VP_135138
Entrez Gene 135138
HGNC 19152
MIM 608427
UniProt Q96M98  
 PACRG identified in exosomes derived from the following tissue/cell type
Chondrocytes 35931686    
Chondrocytes 35931686    
 Gene ontology annotations for PACRG
Molecular Function
    alpha-tubulin binding GO:0043014 IDA
    heat shock protein binding GO:0031072 IPI
    Hsp70 protein binding GO:0030544 IPI
    chaperone binding GO:0051087 IPI
    ubiquitin protein ligase binding GO:0031625 IPI
    actin binding GO:0003779 IDA
    Hsp90 protein binding GO:0051879 IDA
    G-protein coupled receptor binding GO:0001664 IPI
    beta-tubulin binding GO:0048487 IDA
Biological Process
    spermatid development GO:0007286 IEA
    negative regulation of cell death GO:0060548 IMP
    cellular response to unfolded protein GO:0034620 TAS
Subcellular Localization
    neuron projection GO:0043005 IDA
    cell body GO:0044297 IEA
    mitochondrion GO:0005739 IEA
    vesicle GO:0031982 IDA
    nucleus GO:0005634 IDA
    cytosol GO:0005829 IDA
    sperm midpiece GO:0097225 IEA
 Experiment description of studies that identified PACRG in exosomes
1
Experiment ID 497
MISEV standards
EV Biophysical techniques
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
EV Enriched markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD.
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 498
MISEV standards
EM
EV Biophysical techniques
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
EV Enriched markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD.
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for PACRG
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which PACRG is involved
No pathways found





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