Gene description for NEK10
Gene name NIMA-related kinase 10
Gene symbol NEK10
Other names/aliases -
Species Homo sapiens
 Database cross references - NEK10
ExoCarta ExoCarta_152110
Entrez Gene 152110
HGNC 18592
UniProt Q6ZWH5  
 NEK10 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
Squamous carcinoma cells 20124223    
 Gene ontology annotations for NEK10
Molecular Function
    ATP binding GO:0005524 IEA
    metal ion binding GO:0046872 IEA
    protein kinase activity GO:0004672 IDA
    protein serine/threonine kinase activity GO:0004674 IEA
Biological Process
    regulation of cell cycle G2/M phase transition GO:1902749 IMP
    protein phosphorylation GO:0006468 IDA
    regulation of ERK1 and ERK2 cascade GO:0070372 IMP
    positive regulation of MAP kinase activity GO:0043406 IMP
    positive regulation of protein autophosphorylation GO:0031954 IDA
Subcellular Localization
    protein kinase complex GO:1902911 IDA
 Experiment description of studies that identified NEK10 in exosomes
1
Experiment ID 126
ISEV standards
EV Biophysical techniques
GAPDH
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
2
Experiment ID 191
ISEV standards
EV Biophysical techniques
Alix
EV Cytosolic markers
CD81|CD9
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for NEK10
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which NEK10 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here