ExoCarta: Gene summary

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Gene description for Ighm
Gene name	immunoglobulin heavy constant mu
Gene symbol	Ighm
Other names/aliases	AI326478 Igh-6 Igh-M Igh6 Igm muH
Species	Mus musculus
Database cross references - Ighm
ExoCarta	ExoCarta_16019
Vesiclepedia	VP_16019
Entrez Gene	16019
Ighm identified in exosomes derived from the following tissue/cell type
Faeces	33431899
Faeces	33431899

Gene ontology annotations for Ighm

Molecular Function
	transmembrane signaling receptor activity	GO:0004888	IDA
	protein binding	GO:0005515	IPI
	antigen binding	GO:0003823	IDA
Biological Process
	positive regulation of MAPK cascade	GO:0043410	IDA
	positive regulation of B cell activation	GO:0050871	IDA
	defense response to Gram-negative bacterium	GO:0050829	IMP
	immunoglobulin mediated immune response	GO:0016064	IDA
	positive regulation of B cell proliferation	GO:0030890	IDA
	B cell receptor signaling pathway	GO:0050853	IDA
	antigen processing and presentation	GO:0019882	IDA
	early endosome to late endosome transport	GO:0045022	IDA
	activation of MAPK activity	GO:0000187	IDA
	positive regulation of peptidyl-tyrosine phosphorylation	GO:0050731	IDA
	positive regulation of endocytosis	GO:0045807	IDA
	humoral immune response mediated by circulating immunoglobulin	GO:0002455	IDA
Subcellular Localization
	extracellular space	GO:0005615	IDA
	membrane	GO:0016020	IEA
	external side of plasma membrane	GO:0009897	IDA
	B cell receptor complex	GO:0019815	IDA
	perinuclear region of cytoplasm	GO:0048471	IDA
	immunoglobulin complex, circulating	GO:0042571	IDA
	integral component of membrane	GO:0016021	IEA
	extracellular region	GO:0005576	IEA
	plasma membrane	GO:0005886	IEA

Experiment description of studies that identified Ighm in exosomes

Experiment ID

303

MISEV standards
✔ EM	EV Biophysical techniques
✔ Cd63\|Cd81\|Cd9	EV Enriched markers
✘	EV Negative markers
✔ NTA	EV Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

33431899

Organism

Mus musculus

Experiment description

High-fat diet-induced upregulation of exosomal phosphatidylcholine contributes to insulin resistance

Authors

Kumar A, Sundaram K, Mu J, Dryden GW, Sriwastva MK, Lei C, Zhang L, Qiu X, Xu F, Yan J, Zhang X, Park JW, Merchant ML, Bohler HCL, Wang B, Zhang S, Qin C, Xu Z, Han X, McClain CJ, Teng Y, Zhang HG.

Journal name

Nat Commun

Publication year

2021

Sample

Faeces

Sample name

Intestinal epithelial cells - C57BL/6

Isolation/purification methods

Differential centrifugation
Ultracentrifugation
Sucrose density gradient centrifugation

Flotation density

Molecules identified in the study

Protein
Lipid
miRNA

Methods used in the study

Western blotting
Mass spectrometry
Immunofluorescence
miRNA array
HPLC