Gene description for DBH
Gene name dopamine beta-hydroxylase (dopamine beta-monooxygenase)
Gene symbol DBH
Other names/aliases DBM
Species Homo sapiens
 Database cross references - DBH
ExoCarta ExoCarta_1621
Entrez Gene 1621
HGNC 2689
MIM 609312
UniProt P09172  
 DBH identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for DBH
Molecular Function
    copper ion binding GO:0005507 IEA
    catalytic activity GO:0003824 TAS
    L-ascorbic acid binding GO:0031418 IEA
    dopamine beta-monooxygenase activity GO:0004500 TAS
Biological Process
    homoiothermy GO:0042309 IEA
    response to pain GO:0048265 IEA
    dopamine catabolic process GO:0042420 IEA
    behavioral response to ethanol GO:0048149 IEA
    leukocyte migration GO:0050900 IEA
    leukocyte mediated immunity GO:0002443 IEA
    maternal behavior GO:0042711 IEA
    visual learning GO:0008542 IEA
    positive regulation of vasoconstriction GO:0045907 IEA
    oxidation-reduction process GO:0055114 IEA
    blood vessel remodeling GO:0001974 IEA
    regulation of extrinsic apoptotic signaling pathway GO:2001236 IEA
    synaptic transmission GO:0007268 TAS
    response to amphetamine GO:0001975 IEA
    memory GO:0007613 IEA
    norepinephrine biosynthetic process GO:0042421 IEA
    fear response GO:0042596 IEA
    cytokine production GO:0001816 IEA
    locomotory behavior GO:0007626 IEA
    cellular nitrogen compound metabolic process GO:0034641 TAS
    regulation of cell proliferation GO:0042127 IEA
    small molecule metabolic process GO:0044281 TAS
    glucose homeostasis GO:0042593 IEA
    catecholamine biosynthetic process GO:0042423 TAS
Subcellular Localization
    secretory granule lumen GO:0034774 TAS
    cytoplasm GO:0005737 TAS
    transport vesicle membrane GO:0030658 IEA
    chromaffin granule membrane GO:0042584 IEA
    extracellular region GO:0005576 NAS
    chromaffin granule lumen GO:0034466 IEA
    membrane GO:0016020 TAS
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified DBH in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for DBH
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DBH 1621
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which DBH is involved
PathwayEvidenceSource
Catecholamine biosynthesis TAS Reactome





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