Gene description for Itgb3
Gene name integrin beta 3
Gene symbol Itgb3
Other names/aliases CD61
GP3A
INGRB3
Species Mus musculus
 Database cross references - Itgb3
ExoCarta ExoCarta_16416
Vesiclepedia VP_16416
Entrez Gene 16416
UniProt O54890  
 Itgb3 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Itgb3
Molecular Function
    fibronectin binding GO:0001968 ISO
    peptide binding GO:0042277 ISO
    extracellular matrix binding GO:0050840 ISO
    protein disulfide isomerase activity GO:0003756 ISO
    vascular endothelial growth factor receptor 2 binding GO:0043184 ISO
    identical protein binding GO:0042802 ISO
    cell adhesion molecule binding GO:0050839 ISO
    receptor activity GO:0004872 IEA
    protease binding GO:0002020 ISO
    protein binding GO:0005515 IPI
    integrin binding GO:0005178 IPI
    fibrinogen binding GO:0070051 ISO
Biological Process
    positive regulation of osteoclast differentiation GO:0045672 IC
    negative regulation of macrophage derived foam cell differentiation GO:0010745 ISO
    angiogenesis involved in wound healing GO:0060055 IEA
    negative regulation of lipid transport GO:0032369 ISO
    integrin-mediated signaling pathway GO:0007229 ISO
    cell-substrate junction assembly GO:0007044 IDA
    negative regulation of lipid storage GO:0010888 ISO
    viral entry into host cell GO:0046718 ISO
    activation of protein kinase activity GO:0032147 ISO
    apolipoprotein A-I-mediated signaling pathway GO:0038027 ISO
    cell projection morphogenesis GO:0048858 IC
    heterotypic cell-cell adhesion GO:0034113 ISO
    positive regulation of cell adhesion mediated by integrin GO:0033630 ISO
    regulation of cell migration GO:0030334 IMP
    positive regulation of endothelial cell proliferation GO:0001938 ISO
    positive regulation of MAPK cascade GO:0043410 ISO
    cell-matrix adhesion GO:0007160 ISO
    positive regulation of ERK1 and ERK2 cascade GO:0070374 ISO
    regulation of G-protein coupled receptor protein signaling pathway GO:0008277 ISO
    positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 ISO
    positive regulation of smooth muscle cell migration GO:0014911 ISO
    protein folding GO:0006457 ISO
    negative chemotaxis GO:0050919 ISO
    substrate adhesion-dependent cell spreading GO:0034446 ISO
    smooth muscle cell migration GO:0014909 ISO
    platelet aggregation GO:0070527 ISO
    positive regulation of cell migration GO:0030335 IMP
    positive regulation of bone resorption GO:0045780 ISO
    positive regulation of endothelial cell migration GO:0010595 ISO
    positive regulation of glomerular mesangial cell proliferation GO:0072126 ISO
    negative regulation of low-density lipoprotein particle receptor biosynthetic process GO:0045715 ISO
    negative regulation of lipoprotein metabolic process GO:0050748 ISO
    platelet activation GO:0030168 ISO
    regulation of release of sequestered calcium ion into cytosol GO:0051279 ISO
    cell adhesion GO:0007155 ISO
    positive regulation of leukocyte migration GO:0002687 ISO
    cell-substrate adhesion GO:0031589 ISO
    cell growth GO:0016049 ISO
    positive regulation of angiogenesis GO:0045766 ISO
    negative regulation of cell death GO:0060548 ISO
    positive regulation of osteoblast proliferation GO:0033690 IMP
    cell migration GO:0016477 ISO
    positive regulation of smooth muscle cell proliferation GO:0048661 ISO
    positive regulation of fibroblast migration GO:0010763 ISO
    positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway GO:1900731 ISO
    cellular calcium ion homeostasis GO:0006874 ISO
Subcellular Localization
    receptor complex GO:0043235 ISO
    external side of plasma membrane GO:0009897 IDA
    membrane GO:0016020 ISO
    plasma membrane GO:0005886 ISO
    apical plasma membrane GO:0016324 ISO
    focal adhesion GO:0005925 ISO
    melanosome GO:0042470 ISO
    extracellular exosome GO:0070062 ISO
    filopodium membrane GO:0031527 ISO
    integrin alphav-beta3 complex GO:0034683 ISO
    lamellipodium membrane GO:0031258 ISO
    ruffle membrane GO:0032587 ISO
    integrin alpha9-beta1 complex GO:0034679 TAS
    nucleus GO:0005634 ISO
    cell surface GO:0009986 ISO
    cell projection GO:0042995 IEA
    cell junction GO:0030054 IEA
    integral component of membrane GO:0016021 IEA
    microvillus membrane GO:0031528 ISO
    alpha9-beta1 integrin-ADAM8 complex GO:0071133 IDA
    integrin complex GO:0008305 ISO
 Experiment description of studies that identified Itgb3 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Itgb3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Ubqln2  
Reconstituted Complex Mus musculus
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