Gene description for Krt4
Gene name keratin 4
Gene symbol Krt4
Other names/aliases AW108092
K4
Krt-2.4
Krt2-4
Species Mus musculus
 Database cross references - Krt4
ExoCarta ExoCarta_16682
Vesiclepedia VP_16682
Entrez Gene 16682
UniProt P07744  
 Krt4 identified in exosomes derived from the following tissue/cell type
Oligodendrocytes 21136642    
 Gene ontology annotations for Krt4
Molecular Function
    structural constituent of skin epidermis GO:0030280 IBA
Biological Process
    cytoskeleton organization GO:0007010 IEA
    cytoskeleton organization GO:0007010 ISO
    epithelial cell differentiation GO:0030855 IMP
    keratinization GO:0031424 IBA
    intermediate filament organization GO:0045109 IBA
    negative regulation of epithelial cell proliferation GO:0050680 IMP
Subcellular Localization
    cell surface GO:0009986 IEA
    cell surface GO:0009986 ISO
    keratin filament GO:0045095 IBA
    keratin filament GO:0045095 ISO
    keratin filament GO:0045095 TAS
    intermediate filament cytoskeleton GO:0045111 ISO
 Experiment description of studies that identified Krt4 in exosomes
1
Experiment ID 33
MISEV standards
✔
EM|IEM
Biophysical techniques
✔
Alix|TSG101
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21136642    
Organism Mus musculus
Experiment description Oligodendrocytes secrete exosomes containing major myelin and stress-protective proteins: Trophic support for axons?
Authors "Kramer-Albers EM, Bretz N, Tenzer S, Winterstein C, Mobius W, Berger H, Nave KA, Schild H, Trotter J"
Journal name PROTEOMICS_CL
Publication year 2007
Sample Oligodendrocytes
Sample name Oligodendrocytes
Oli-neu
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.10-1.14 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for Krt4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Invs  
Affinity Capture-MS Mus musculus
2 Eps15 13858
Co-fractionation Mus musculus
3 Krt13 16663
Co-fractionation Mus musculus
4 Tnni2  
Co-fractionation Mus musculus
5 Pik3r2  
Co-fractionation Mus musculus
6 Ubash3b  
Co-fractionation Mus musculus
7 Tgm3  
Co-fractionation Mus musculus
8 Myh1  
Co-fractionation Mus musculus
9 Fancd2  
Affinity Capture-MS Mus musculus
10 Atp2a1  
Co-fractionation Mus musculus
View the network image/svg+xml
 Pathways in which Krt4 is involved
PathwayEvidenceSource
Developmental Biology IEA Reactome
Formation of the cornified envelope IEA Reactome
Keratinization IEA Reactome





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