Gene description for Krt4
Gene name keratin 4
Gene symbol Krt4
Other names/aliases AW108092
Species Mus musculus
 Database cross references - Krt4
ExoCarta ExoCarta_16682
Entrez Gene 16682
UniProt P07744  
 Krt4 identified in exosomes derived from the following tissue/cell type
Oligodendrocytes 21136642    
 Gene ontology annotations for Krt4
Molecular Function
    protein heterodimerization activity GO:0046982 TAS
    structural molecule activity GO:0005198 IEA
Biological Process
    negative regulation of epithelial cell proliferation GO:0050680 IMP
    epithelial cell differentiation GO:0030855 IMP
    embryo development GO:0009790 TAS
    cytoskeleton organization GO:0007010 ISO
Subcellular Localization
    keratin filament GO:0045095 TAS
    cell surface GO:0009986 ISO
    nucleus GO:0005634 ISO
    intermediate filament GO:0005882 IEA
    intermediate filament cytoskeleton GO:0045111 ISO
 Experiment description of studies that identified Krt4 in exosomes
Experiment ID 33
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21136642    
Organism Mus musculus
Experiment description Oligodendrocytes secrete exosomes containing major myelin and stress-protective proteins: Trophic support for axons?
Authors Kramer-Albers EM, Bretz N, Tenzer S, Winterstein C, Mobius W, Berger H, Nave KA, Schild H, Trotter J
Journal name PROTEOMICS_CL
Publication year 2007
Sample Oligodendrocytes
Sample name Oligodendrocytes
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.10-1.14 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for Krt4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Krt4 is involved
No pathways found

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