Gene description for DNAH5
Gene name dynein, axonemal, heavy chain 5
Gene symbol DNAH5
Other names/aliases CILD3
DNAHC5
HL1
KTGNR
PCD
Species Homo sapiens
 Database cross references - DNAH5
ExoCarta ExoCarta_1767
Vesiclepedia VP_1767
Entrez Gene 1767
HGNC 2950
MIM 603335
UniProt Q8TE73  
 DNAH5 identified in sEVs derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for DNAH5
Molecular Function
    ATP binding GO:0005524 IEA
    minus-end-directed microtubule motor activity GO:0008569 IBA
    ATP hydrolysis activity GO:0016887 IEA
    dynein intermediate chain binding GO:0045505 IBA
    dynein light intermediate chain binding GO:0051959 IBA
Biological Process
    cilium movement GO:0003341 IMP
    epithelial cilium movement involved in extracellular fluid movement GO:0003351 IEA
    determination of left/right symmetry GO:0007368 IMP
    heart development GO:0007507 IEA
    lateral ventricle development GO:0021670 IEA
    flagellated sperm motility GO:0030317 IMP
    outer dynein arm assembly GO:0036158 IBA
    outer dynein arm assembly GO:0036158 IMP
    establishment of localization in cell GO:0051649 IEA
    cilium assembly GO:0060271 IMP
    cilium movement involved in cell motility GO:0060294 IBA
Subcellular Localization
    extracellular region GO:0005576 IEA
    cytoplasm GO:0005737 IDA
    microtubule GO:0005874 IEA
    axoneme GO:0005930 IDA
    motile cilium GO:0031514 IDA
    outer dynein arm GO:0036157 IBA
    outer dynein arm GO:0036157 IDA
    outer dynein arm GO:0036157 IMP
    9+0 motile cilium GO:0097728 IEA
    9+2 motile cilium GO:0097729 IBA
    9+2 motile cilium GO:0097729 IDA
 Experiment description of studies that identified DNAH5 in sEVs
1
Experiment ID 275
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
✔
AIF
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for DNAH5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MEX3A  
Affinity Capture-RNA Homo sapiens
2 PSMD14 10213
Affinity Capture-MS Homo sapiens
3 ANLN 54443
Affinity Capture-MS Homo sapiens
4 ACTB 60
Cross-Linking-MS (XL-MS) Homo sapiens
View the network image/svg+xml
 Pathways in which DNAH5 is involved
No pathways found





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