Gene description for DNAH5
Gene name dynein, axonemal, heavy chain 5
Gene symbol DNAH5
Other names/aliases CILD3
DNAHC5
HL1
KTGNR
PCD
Species Homo sapiens
 Database cross references - DNAH5
ExoCarta ExoCarta_1767
Entrez Gene 1767
HGNC 2950
MIM 603335
UniProt Q8TE73  
 DNAH5 identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for DNAH5
Molecular Function
    ATPase activity GO:0016887 IEA
    ATP binding GO:0005524 IEA
    microtubule motor activity GO:0003777 NAS
Biological Process
    left/right axis specification GO:0070986 IEA
    outer dynein arm assembly GO:0036158 IMP
    biological_process GO:0008150 ND
    lateral ventricle development GO:0021670 IEA
    determination of left/right symmetry GO:0007368 IMP
    metabolic process GO:0008152 IEA
    sperm motility GO:0030317 IMP
    cilium movement GO:0003341 IMP
Subcellular Localization
    microtubule GO:0005874 IEA
    axoneme GO:0005930 IDA
    cellular_component GO:0005575 ND
    outer dynein arm GO:0036157 IMP
 Experiment description of studies that identified DNAH5 in exosomes
1
Experiment ID 275
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|RAB5A
EV Cytosolic markers
CD9|CD82|CD63|CD81
EV Membrane markers
AIF
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for DNAH5
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which DNAH5 is involved
No pathways found





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