Gene description for Ptgs2
Gene name prostaglandin-endoperoxide synthase 2
Gene symbol Ptgs2
Other names/aliases COX2
Species Mus musculus
 Database cross references - Ptgs2
ExoCarta ExoCarta_19225
Entrez Gene 19225
UniProt Q05769  
 Ptgs2 identified in exosomes derived from the following tissue/cell type
Basophilic leukemia cells 20424270    
 Gene ontology annotations for Ptgs2
Molecular Function
    dioxygenase activity GO:0051213 IEA
    heme binding GO:0020037 IDA
    peroxidase activity GO:0004601 IEA
    oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen GO:0016702 ISO
    prostaglandin-endoperoxide synthase activity GO:0004666 ISO
    protein homodimerization activity GO:0042803 IPI
    enzyme binding GO:0019899 ISO
    lipid binding GO:0008289 ISO
    metal ion binding GO:0046872 IEA
    oxidoreductase activity GO:0016491 IEA
Biological Process
    positive regulation of apoptotic process GO:0043065 ISO
    positive regulation of nitric oxide biosynthetic process GO:0045429 ISO
    positive regulation of vasoconstriction GO:0045907 ISO
    ovulation GO:0030728 ISO
    response to lipopolysaccharide GO:0032496 ISO
    positive regulation of cell proliferation GO:0008284 ISO
    bone mineralization GO:0030282 ISO
    positive regulation of fever generation GO:0031622 ISO
    positive regulation of brown fat cell differentiation GO:0090336 IMP
    regulation of blood pressure GO:0008217 IMP
    oxidation-reduction process GO:0055114 IDA
    fatty acid metabolic process GO:0006631 IEA
    angiogenesis GO:0001525 ISO
    anagen GO:0042640 IMP
    decidualization GO:0046697 ISO
    inflammatory response GO:0006954 ISO
    brown fat cell differentiation GO:0050873 IMP
    cellular response to fluid shear stress GO:0071498 IDA
    prostaglandin biosynthetic process GO:0001516 ISO
    regulation of cell proliferation GO:0042127 IGI
    positive regulation of smooth muscle cell proliferation GO:0048661 ISO
    cyclooxygenase pathway GO:0019371 ISO
    maintenance of blood-brain barrier GO:0035633 ISO
    positive regulation of synaptic transmission, glutamatergic GO:0051968 ISO
    positive regulation of smooth muscle contraction GO:0045987 ISO
    keratinocyte differentiation GO:0030216 NAS
    positive regulation of fibroblast growth factor production GO:0090271 ISO
    embryo implantation GO:0007566 ISO
    negative regulation of cell cycle GO:0045786 ISO
    positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 ISO
    response to oxidative stress GO:0006979 IEA
    positive regulation of synaptic plasticity GO:0031915 ISO
    positive regulation of transforming growth factor beta production GO:0071636 ISO
    positive regulation of cell death GO:0010942 ISO
    memory GO:0007613 ISO
    sensory perception of pain GO:0019233 ISO
    response to cytokine GO:0034097 ISO
    learning GO:0007612 ISO
    negative regulation of calcium ion transport GO:0051926 ISO
    negative regulation of synaptic transmission, dopaminergic GO:0032227 ISO
    negative regulation of smooth muscle contraction GO:0045986 ISO
    prostaglandin metabolic process GO:0006693 IEA
    positive regulation of vascular endothelial growth factor production GO:0010575 ISO
    positive regulation of NF-kappaB import into nucleus GO:0042346 ISO
    fatty acid biosynthetic process GO:0006633 IEA
    positive regulation of platelet-derived growth factor production GO:0090362 ISO
    negative regulation of cell proliferation GO:0008285 ISO
    lipid metabolic process GO:0006629 IEA
Subcellular Localization
    intracellular membrane-bounded organelle GO:0043231 IEA
    neuron projection GO:0043005 ISO
    endoplasmic reticulum GO:0005783 ISO
    membrane GO:0016020 IEA
    protein complex GO:0043234 ISO
    caveola GO:0005901 ISO
    nucleus GO:0005634 IDA
    cytoplasm GO:0005737 ISO
 Experiment description of studies that identified Ptgs2 in exosomes
Experiment ID 89
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method FACS
PubMed ID 20424270    
Organism Rattus norvegicus
Experiment description Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins.
Authors Subra C, Grand D, Laulagnier K, Stella A, Lambeau G, Paillasse M, De Medina P, Monsarrat B, Perret B, Silvente-Poirot S, Poirot M, Record M.
Journal name JLR
Publication year 2010
Sample Basophilic leukemia cells
Sample name RBL-2H3
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Gas chromatography
Thin layer chromatography
Mass spectrometry [Qstar XL]
 Protein-protein interactions for Ptgs2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.

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