Gene description for Ptgs2
Gene name	prostaglandin-endoperoxide synthase 2
Gene symbol	Ptgs2
Other names/aliases	COX2 Cox-2 PGHS-2 PHS-2 Pghs2 TIS10
Species	Mus musculus
Database cross references - Ptgs2
ExoCarta	ExoCarta_19225
Entrez Gene	19225
UniProt	Q05769
Ptgs2 identified in exosomes derived from the following tissue/cell type
Basophilic leukemia cells	20424270

Gene ontology annotations for Ptgs2

Molecular Function     dioxygenase activity GO:0051213 IEA     heme binding GO:0020037 IDA     peroxidase activity GO:0004601 IEA     oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen GO:0016702 ISO     prostaglandin-endoperoxide synthase activity GO:0004666 ISO     protein homodimerization activity GO:0042803 IPI     enzyme binding GO:0019899 ISO     lipid binding GO:0008289 ISO     metal ion binding GO:0046872 IEA     oxidoreductase activity GO:0016491 IEA Biological Process     positive regulation of apoptotic process GO:0043065 ISO     positive regulation of nitric oxide biosynthetic process GO:0045429 ISO     positive regulation of vasoconstriction GO:0045907 ISO     ovulation GO:0030728 ISO     response to lipopolysaccharide GO:0032496 ISO     positive regulation of cell proliferation GO:0008284 ISO     bone mineralization GO:0030282 ISO     positive regulation of fever generation GO:0031622 ISO     positive regulation of brown fat cell differentiation GO:0090336 IMP     regulation of blood pressure GO:0008217 IMP     oxidation-reduction process GO:0055114 IDA     fatty acid metabolic process GO:0006631 IEA     angiogenesis GO:0001525 ISO     anagen GO:0042640 IMP     decidualization GO:0046697 ISO     inflammatory response GO:0006954 ISO     brown fat cell differentiation GO:0050873 IMP     cellular response to fluid shear stress GO:0071498 IDA     prostaglandin biosynthetic process GO:0001516 ISO     regulation of cell proliferation GO:0042127 IGI     positive regulation of smooth muscle cell proliferation GO:0048661 ISO     cyclooxygenase pathway GO:0019371 ISO     maintenance of blood-brain barrier GO:0035633 ISO     positive regulation of synaptic transmission, glutamatergic GO:0051968 ISO     positive regulation of smooth muscle contraction GO:0045987 ISO     keratinocyte differentiation GO:0030216 NAS     positive regulation of fibroblast growth factor production GO:0090271 ISO     embryo implantation GO:0007566 ISO     negative regulation of cell cycle GO:0045786 ISO     positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 ISO     response to oxidative stress GO:0006979 IEA     positive regulation of synaptic plasticity GO:0031915 ISO     positive regulation of transforming growth factor beta production GO:0071636 ISO     positive regulation of cell death GO:0010942 ISO     memory GO:0007613 ISO     sensory perception of pain GO:0019233 ISO     response to cytokine GO:0034097 ISO     learning GO:0007612 ISO     negative regulation of calcium ion transport GO:0051926 ISO     negative regulation of synaptic transmission, dopaminergic GO:0032227 ISO     negative regulation of smooth muscle contraction GO:0045986 ISO     prostaglandin metabolic process GO:0006693 IEA     positive regulation of vascular endothelial growth factor production GO:0010575 ISO     positive regulation of NF-kappaB import into nucleus GO:0042346 ISO     fatty acid biosynthetic process GO:0006633 IEA     positive regulation of platelet-derived growth factor production GO:0090362 ISO     negative regulation of cell proliferation GO:0008285 ISO     lipid metabolic process GO:0006629 IEA Subcellular Localization     intracellular membrane-bounded organelle GO:0043231 IEA     neuron projection GO:0043005 ISO     endoplasmic reticulum GO:0005783 ISO     membrane GO:0016020 IEA     protein complex GO:0043234 ISO     caveola GO:0005901 ISO     nucleus GO:0005634 IDA     cytoplasm GO:0005737 ISO