Gene description for Rps6ka2
Gene name ribosomal protein S6 kinase, polypeptide 2
Gene symbol Rps6ka2
Other names/aliases 90kDa
D17Wsu134e
Rps6ka-rs1
Rsk3
p90rsk
pp90rsk
Species Mus musculus
 Database cross references - Rps6ka2
ExoCarta ExoCarta_20112
Entrez Gene 20112
UniProt Q9WUT3  
 Rps6ka2 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Rps6ka2
Molecular Function
    protein serine/threonine kinase activity GO:0004674 IDA
    magnesium ion binding GO:0000287 IEA
    transferase activity, transferring phosphorus-containing groups GO:0016772 IEA
    kinase activity GO:0016301 IEA
    protein serine/threonine/tyrosine kinase activity GO:0004712 ISO
    protein binding GO:0005515 IPI
    transferase activity GO:0016740 IEA
    ATP binding GO:0005524 IEA
    protein kinase activity GO:0004672 IDA
    nucleotide binding GO:0000166 IEA
    ribosomal protein S6 kinase activity GO:0004711 IDA
Biological Process
    cardiac muscle cell apoptotic process GO:0010659 IDA
    negative regulation of cell cycle GO:0045786 ISO
    phosphorylation GO:0016310 IEA
    cellular response to carbohydrate stimulus GO:0071322 IDA
    negative regulation of meiotic nuclear division GO:0045835 IDA
    positive regulation of apoptotic process GO:0043065 ISO
    oocyte maturation GO:0001556 IDA
    brain renin-angiotensin system GO:0002035 IDA
    positive regulation of gene expression GO:0010628 IDA
    heart development GO:0007507 IDA
    protein phosphorylation GO:0006468 ISO
    heart contraction GO:0060047 IDA
    regulation of protein processing GO:0070613 IMP
    intracellular signal transduction GO:0035556 IBA
    peptidyl-serine phosphorylation GO:0018105 IDA
    negative regulation of cell proliferation GO:0008285 ISO
    regulation of translation GO:0006417 IBA
Subcellular Localization
    nuclear membrane GO:0031965 ISO
    nucleus GO:0005634 ISO
    spindle GO:0005819 IDA
    cytoplasm GO:0005737 ISO
    nucleoplasm GO:0005654 ISO
    intracellular GO:0005622 IBA
 Experiment description of studies that identified Rps6ka2 in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Rps6ka2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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