Gene description for Rps6ka1
Gene name ribosomal protein S6 kinase polypeptide 1
Gene symbol Rps6ka1
Other names/aliases Mapkapk-1a
Rsk
Rsk-1
Rsk1
S6K-alpha-1
p90-Rsk1
p90Rsk1
p90S6K
p90rsk
Species Mus musculus
 Database cross references - Rps6ka1
ExoCarta ExoCarta_20111
Entrez Gene 20111
UniProt P18653  
 Rps6ka1 identified in exosomes derived from the following tissue/cell type
Mast cells 11145662    
 Gene ontology annotations for Rps6ka1
Molecular Function
    magnesium ion binding GO:0000287 IEA
    cysteine-type endopeptidase inhibitor activity involved in apoptotic process GO:0043027 ISO
    protein kinase activity GO:0004672 IEA
    kinase activity GO:0016301 IDA
    transferase activity GO:0016740 IEA
    protein serine/threonine/tyrosine kinase activity GO:0004712 ISO
    ribosomal protein S6 kinase activity GO:0004711 IBA
    nucleotide binding GO:0000166 IEA
    transcription factor binding GO:0008134 ISO
    protein serine/threonine kinase activity GO:0004674 ISO
    ATP binding GO:0005524 IEA
    transferase activity, transferring phosphorus-containing groups GO:0016772 IEA
Biological Process
    positive regulation of hepatic stellate cell activation GO:2000491 ISO
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISO
    regulation of translation GO:0006417 IBA
    negative regulation of apoptotic process GO:0043066 ISO
    phosphorylation GO:0016310 IDA
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 ISO
    positive regulation of transcription, DNA-templated GO:0045893 ISO
    protein phosphorylation GO:0006468 ISO
    intracellular signal transduction GO:0035556 IBA
    hepatocyte proliferation GO:0072574 IDA
Subcellular Localization
    cytoplasm GO:0005737 ISO
    spindle GO:0005819 IDA
    nucleus GO:0005634 ISO
 Experiment description of studies that identified Rps6ka1 in exosomes
1
Experiment ID 5
ISEV standards
EM|IEM
EV Biophysical techniques
EV Cytosolic markers
CD86|CD80
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 11145662    
Organism Mus musculus
Experiment description Mast cell-dependent B and T lymphocyte activation is mediated by the secretion of immunologically active exosomes.
Authors Skokos D, Le Panse S, Villa I, Rousselle JC, Peronet R, David B, Namane A, Mecheri S
Journal name JIMMU
Publication year 2001
Sample Mast cells
Sample name P815
MC9
Bone marrow-derived mast cells
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [MALDI TOF]
ELISA
 Protein-protein interactions for Rps6ka1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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