Gene description for Sod2
Gene name superoxide dismutase 2, mitochondrial
Gene symbol Sod2
Other names/aliases MnSOD
Sod-2
Species Mus musculus
 Database cross references - Sod2
ExoCarta ExoCarta_20656
Entrez Gene 20656
UniProt P09671  
 Sod2 identified in exosomes derived from the following tissue/cell type
Pancreatic cells 19351151    
 Gene ontology annotations for Sod2
Molecular Function
    manganese ion binding GO:0030145 ISO
    DNA binding GO:0003677 ISO
    oxygen binding GO:0019825 ISO
    oxidoreductase activity GO:0016491 IEA
    metal ion binding GO:0046872 IEA
    protein binding GO:0005515 IPI
    identical protein binding GO:0042802 ISO
    superoxide dismutase activity GO:0004784 ISO
Biological Process
    iron ion homeostasis GO:0055072 IMP
    response to hydrogen peroxide GO:0042542 IMP
    regulation of mitochondrial membrane potential GO:0051881 IMP
    response to superoxide GO:0000303 ISO
    response to oxidative stress GO:0006979 IMP
    response to activity GO:0014823 IMP
    heart development GO:0007507 IMP
    response to drug GO:0042493 ISO
    regulation of catalytic activity GO:0050790 IMP
    negative regulation of apoptotic process GO:0043066 ISO
    vasodilation GO:0042311 IMP
    release of cytochrome c from mitochondria GO:0001836 IMP
    negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902176 ISO
    intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 IMP
    age-dependent response to oxidative stress GO:0001306 IMP
    regulation of blood pressure GO:0008217 IMP
    removal of superoxide radicals GO:0019430 ISO
    erythrophore differentiation GO:0048773 IMP
    negative regulation of fibroblast proliferation GO:0048147 IDA
    protein homooligomerization GO:0051260 ISO
    respiratory electron transport chain GO:0022904 IMP
    hydrogen peroxide metabolic process GO:0042743 ISO
    protein homotetramerization GO:0051289 ISO
    apoptotic mitochondrial changes GO:0008637 IMP
    hydrogen peroxide biosynthetic process GO:0050665 ISO
    response to nutrient levels GO:0031667 ISO
    age-dependent response to reactive oxygen species GO:0001315 ISO
    vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure GO:0003069 IMP
    response to reactive oxygen species GO:0000302 IMP
    response to axon injury GO:0048678 IMP
    detection of oxygen GO:0003032 IMP
    neuron development GO:0048666 IMP
    post-embryonic development GO:0009791 IMP
    negative regulation of neuron apoptotic process GO:0043524 ISO
    negative regulation of cell proliferation GO:0008285 ISO
    regulation of transcription from RNA polymerase II promoter GO:0006357 ISO
    glutathione metabolic process GO:0006749 IMP
    positive regulation of nitric oxide biosynthetic process GO:0045429 IMP
    response to hyperoxia GO:0055093 IMP
    negative regulation of fat cell differentiation GO:0045599 IMP
    locomotory behavior GO:0007626 IMP
    oxygen homeostasis GO:0032364 ISO
    superoxide anion generation GO:0042554 IMP
    sensory perception of sound GO:0007605 IMP
    liver development GO:0001889 IMP
    superoxide metabolic process GO:0006801 ISO
    hemopoiesis GO:0030097 IMP
    response to gamma radiation GO:0010332 IGI
    oxidation-reduction process GO:0055114 ISO
    mitochondrion organization GO:0007005 IMP
    intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 IMP
Subcellular Localization
    mitochondrial inner membrane GO:0005743 IDA
    mitochondrion GO:0005739 ISO
    myelin sheath GO:0043209 IDA
    extracellular exosome GO:0070062 ISO
    cytoplasm GO:0005737 ISO
    mitochondrial nucleoid GO:0042645 ISO
    intracellular GO:0005622 IMP
 Experiment description of studies that identified Sod2 in exosomes
1
Experiment ID 188
ISEV standards
EM
EV Biophysical techniques
GAPDH|UCHL1|HSP90
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors Lee HS, Jeong J, Lee KJ.
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Sod2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Sod2 is involved
PathwayEvidenceSource
Detoxification of Reactive Oxygen Species IEA Reactome





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