Gene description for Prdx2
Gene name peroxiredoxin 2
Gene symbol Prdx2
Other names/aliases AL022839
Band-8
NkefB
PRP
PrxII
TDX1
TPx
TPx-B
TR
TSA
Tdpx1
Torin
Species Mus musculus
 Database cross references - Prdx2
ExoCarta ExoCarta_21672
Entrez Gene 21672
UniProt Q61171  
 Prdx2 identified in exosomes derived from the following tissue/cell type
Mov neuroglial cells 15210972    
Oligodendrocytes 21136642    
Pancreatic cells 19351151    
 Gene ontology annotations for Prdx2
Molecular Function
    oxidoreductase activity GO:0016491 IEA
    antioxidant activity GO:0016209 ISO
    peroxidase activity GO:0004601 TAS
    selenium binding GO:0008430 TAS
    protein binding GO:0005515 IPI
    thioredoxin peroxidase activity GO:0008379 TAS
    peroxiredoxin activity GO:0051920 IEA
Biological Process
    cellular response to oxidative stress GO:0034599 ISO
    negative regulation of NF-kappaB transcription factor activity GO:0032088 IMP
    negative regulation of lipopolysaccharide-mediated signaling pathway GO:0031665 IMP
    removal of superoxide radicals GO:0019430 ISO
    response to oxidative stress GO:0006979 TAS
    T cell proliferation GO:0042098 IMP
    homeostasis of number of cells GO:0048872 IMP
    negative regulation of reactive oxygen species metabolic process GO:2000378 IMP
    hydrogen peroxide catabolic process GO:0042744 IMP
    response to lipopolysaccharide GO:0032496 IMP
    negative regulation of extrinsic apoptotic signaling pathway GO:2001237 IMP
    positive regulation of blood coagulation GO:0030194 IMP
    regulation of apoptotic process GO:0042981 ISO
    oxidation-reduction process GO:0055114 ISS
    thymus development GO:0048538 IMP
    negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 IDA
    respiratory burst involved in inflammatory response GO:0002536 IMP
    hydrogen peroxide metabolic process GO:0042743 IMP
    activation of MAPK activity GO:0000187 IMP
    negative regulation of T cell differentiation GO:0045581 IMP
    regulation of hydrogen peroxide metabolic process GO:0010310 IMP
    negative regulation of neuron apoptotic process GO:0043524 ISO
Subcellular Localization
    mitochondrion GO:0005739 IDA
    cytoplasm GO:0005737 IEA
    extracellular exosome GO:0070062 ISO
    myelin sheath GO:0043209 IDA
    cytosol GO:0005829 ISO
 Experiment description of studies that identified Prdx2 in exosomes
1
Experiment ID 39
ISEV standards
IEM
EV Biophysical techniques
TSG101|HSC70
EV Cytosolic markers
FLOT1
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 15210972    
Organism Mus musculus
Experiment description Cells release prions in association with exosomes.
Authors Fevrier B, Vilette D, Archer F, Loew D, Faigle W, Vidal M, Laude H, Raposo G
Journal name PNAS
Publication year 2004
Sample Mov neuroglial cells
Sample name Mov neuroglial cell
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QSTAR]
Western blotting
Immunoelectron Microscopy
2
Experiment ID 33
ISEV standards
EM|IEM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21136642    
Organism Mus musculus
Experiment description Oligodendrocytes secrete exosomes containing major myelin and stress-protective proteins: Trophic support for axons?
Authors Kramer-Albers EM, Bretz N, Tenzer S, Winterstein C, Mobius W, Berger H, Nave KA, Schild H, Trotter J
Journal name PROTEOMICS_CL
Publication year 2007
Sample Oligodendrocytes
Sample name Oligodendrocytes
Oli-neu
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.10-1.14 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QTOF]
Western blotting
Immunoelectron Microscopy
3
Experiment ID 188
ISEV standards
EM
EV Biophysical techniques
GAPDH|UCHL1|HSP90
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19351151    
Organism Mus musculus
Experiment description Characterization of vesicles secreted from insulinoma NIT-1 cells.
Authors Lee HS, Jeong J, Lee KJ.
Journal name J Proteome Res
Publication year 2009
Sample Pancreatic cells
Sample name Pancreatic beta cell (NIT-1)
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Prdx2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Prdx2 is involved
PathwayEvidenceSource
Detoxification of Reactive Oxygen Species IEA Reactome
TP53 Regulates Metabolic Genes IEA Reactome





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