Gene description for Fmnl3
Gene name formin-like 3
Gene symbol Fmnl3
Other names/aliases 2700073B04Rik
FBP11
Wbp3
mKIAA2014
Species Mus musculus
 Database cross references - Fmnl3
ExoCarta ExoCarta_22379
Vesiclepedia VP_22379
Entrez Gene 22379
UniProt Q6ZPF4  
 Fmnl3 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Fmnl3
Molecular Function
    Rho GTPase binding GO:0017048 IEA
    protein binding GO:0005515 IPI
    GTPase activating protein binding GO:0032794 IDA
    actin binding GO:0003779 IEA
Biological Process
    cell migration GO:0016477 ISO
    actin cytoskeleton organization GO:0030036 IEA
    cellular component organization GO:0016043 IEA
    regulation of cell shape GO:0008360 ISO
    cytoskeleton organization GO:0007010 ISO
Subcellular Localization
    cytoplasm GO:0005737 ISO
 Experiment description of studies that identified Fmnl3 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Fmnl3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Fmnl3 is involved
PathwayEvidenceSource
RHO GTPases Activate Formins IEA Reactome





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