Gene description for SSPO
Gene name SCO-spondin
Gene symbol SSPO
Other names/aliases -
Species Homo sapiens
 Database cross references - SSPO
ExoCarta ExoCarta_23145
Entrez Gene 23145
HGNC 21998
UniProt A2VEC9  
 SSPO identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for SSPO
Molecular Function
    peptidase inhibitor activity GO:0030414 IEA
Biological Process
    cell differentiation GO:0030154 IEA
    negative regulation of peptidase activity GO:0010466 IEA
    nervous system development GO:0007399 IEA
    cell adhesion GO:0007155 IEA
Subcellular Localization
    extracellular space GO:0005615 TAS
 Experiment description of studies that identified SSPO in exosomes
1
Experiment ID 224
ISEV standards
✔
EM|AFM
EV Biophysical techniques
✔
Alix|TSG101
EV Cytosolic markers
✔
CD63|CD81
EV Membrane markers
✔
GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for SSPO
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SSPO is involved
PathwayEvidenceSource
O-glycosylation of TSR domain-containing proteins TAS Reactome





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