Gene description for SPIDR
Gene name scaffolding protein involved in DNA repair
Gene symbol SPIDR
Other names/aliases KIAA0146
Species Homo sapiens
 Database cross references - SPIDR
ExoCarta ExoCarta_23514
Entrez Gene 23514
HGNC 28971
MIM 615384
UniProt Q14159  
 SPIDR identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for SPIDR
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    positive regulation of double-strand break repair GO:2000781 IMP
    regulation of double-strand break repair via homologous recombination GO:0010569 IDA
    cellular response to hydroxyurea GO:0072711 IDA
    regulation of establishment of protein localization to chromosome GO:0070202 IDA
    positive regulation of protein complex assembly GO:0031334 IDA
    cellular response to DNA damage stimulus GO:0006974 IDA
    cellular response to camptothecin GO:0072757 IDA
    double-strand break repair via homologous recombination GO:0000724 IMP
    cellular response to ionizing radiation GO:0071479 IDA
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    nuclear chromosome GO:0000228 IDA
 Experiment description of studies that identified SPIDR in exosomes
1
Experiment ID 126
ISEV standards
✘ EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for SPIDR
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SPIDR is involved
No pathways found





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