Gene description for Rab8b
Gene name RAB8B, member RAS oncogene family
Gene symbol Rab8b
Other names/aliases 5930437D16
D330025I23Rik
Species Mus musculus
 Database cross references - Rab8b
ExoCarta ExoCarta_235442
Entrez Gene 235442
UniProt P61028  
 Rab8b identified in exosomes derived from the following tissue/cell type
Microglia 16081791    
 Gene ontology annotations for Rab8b
Molecular Function
    GTP binding GO:0005525 IEA
    nucleotide binding GO:0000166 IEA
    protein binding GO:0005515 IPI
    TPR domain binding GO:0030911 ISO
    GDP binding GO:0019003 ISO
    GTPase activity GO:0003924 IBA
    receptor binding GO:0005102 ISO
Biological Process
    adherens junction organization GO:0034332 ISO
    Rab protein signal transduction GO:0032482 IBA
    positive regulation of cell projection organization GO:0031346 ISO
    regulation of exocytosis GO:0017157 IBA
    positive regulation of corticotropin secretion GO:0051461 ISO
    protein localization to plasma membrane GO:0072659 IBA
    transport GO:0006810 IEA
    synaptic vesicle exocytosis GO:0016079 IBA
    small GTPase mediated signal transduction GO:0007264 IEA
    Golgi vesicle fusion to target membrane GO:0048210 IBA
    protein secretion GO:0009306 IBA
    vesicle docking involved in exocytosis GO:0006904 IBA
    intracellular protein transport GO:0006886 IBA
    protein import into peroxisome membrane GO:0045046 ISO
    protein transport GO:0015031 IEA
    cellular response to insulin stimulus GO:0032869 IBA
    antigen processing and presentation GO:0019882 ISO
Subcellular Localization
    secretory granule membrane GO:0030667 IBA
    perinuclear region of cytoplasm GO:0048471 ISO
    endosome GO:0005768 IBA
    cell tip GO:0051286 ISO
    peroxisomal membrane GO:0005778 ISO
    extracellular exosome GO:0070062 ISO
    trans-Golgi network transport vesicle GO:0030140 IBA
    synaptic vesicle GO:0008021 IBA
    plasma membrane GO:0005886 ISO
    mitochondrion GO:0005739 IDA
    phagocytic vesicle GO:0045335 ISO
    membrane GO:0016020 IEA
    cytoplasmic vesicle GO:0031410 ISO
 Experiment description of studies that identified Rab8b in exosomes
1
Experiment ID 14
ISEV standards
✔
EM
EV Biophysical techniques
✔
RAB7|RAB11
EV Cytosolic markers
✔
CD9|CD63|LAMP1|LAMP2
EV Membrane markers
✔
DNM
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 16081791    
Organism Mus musculus
Experiment description Proteomic analysis of microglia-derived exosomes: metabolic role of the aminopeptidase CD13 in neuropeptide catabolism.
Authors Potolicchio I, Carven GJ, Xu X, Stipp C, Riese RJ, Stern LJ, Santambrogio L
Journal name JIMMU
Publication year 2005
Sample Microglia
Sample name N9
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LCQ DECA XP]
Western blotting
 Protein-protein interactions for Rab8b
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Rab8b is involved
No pathways found





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