Gene description for Hspa8
Gene name	heat shock 70kDa protein 8
Gene symbol	Hspa8
Other names/aliases	Hsc70
Species	Rattus norvegicus
Database cross references - Hspa8
ExoCarta	ExoCarta_24468
Vesiclepedia	VP_24468
Entrez Gene	24468
UniProt	P63018
Hspa8 identified in exosomes derived from the following tissue/cell type
Adipocytes	25998041
Cortical neurones	16446100
Hepatocytes	19367702
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046
Reticulocytes	21828046

Gene ontology annotations for Hspa8

Molecular Function     G protein-coupled receptor binding GO:0001664 ISO     phosphatidylserine binding GO:0001786 IEA     phosphatidylserine binding GO:0001786 ISO     RNA binding GO:0003723 IDA     signaling receptor binding GO:0005102 IPI     protein binding GO:0005515 IPI     ATP binding GO:0005524 IDA     ATP binding GO:0005524 IEA     ATP binding GO:0005524 ISO     ATP hydrolysis activity GO:0016887 IBA     ATP hydrolysis activity GO:0016887 IDA     ATP hydrolysis activity GO:0016887 ISO     enzyme binding GO:0019899 IPI     enzyme binding GO:0019899 ISO     protein-macromolecule adaptor activity GO:0030674 ISO     protein-macromolecule adaptor activity GO:0030674 ISS     heat shock protein binding GO:0031072 IBA     heat shock protein binding GO:0031072 ISO     ubiquitin protein ligase binding GO:0031625 ISO     A1 adenosine receptor binding GO:0031686 IPI     peptide binding GO:0042277 IDA     ADP binding GO:0043531 IDA     protein folding chaperone GO:0044183 IBA     receptor ligand activity GO:0048018 ISO     unfolded protein binding GO:0051082 IEA     unfolded protein binding GO:0051082 IMP     unfolded protein binding GO:0051082 ISO     protein-folding chaperone binding GO:0051087 ISO     C3HC4-type RING finger domain binding GO:0055131 ISO     ATP-dependent protein disaggregase activity GO:0140545 ISO     ATP-dependent protein folding chaperone GO:0140662 IEA     prostaglandin binding GO:1904593 IPI     clathrin-uncoating ATPase activity GO:1990833 IDA Biological Process     G1/S transition of mitotic cell cycle GO:0000082 IEP     kidney development GO:0001822 IEP     positive regulation of T cell mediated cytotoxicity GO:0001916 IMP     mRNA processing GO:0006397 IEA     protein folding GO:0006457 IEA     protein folding GO:0006457 ISO     protein import into nucleus GO:0006606 IMP     signal transduction GO:0007165 IEA     skeletal muscle tissue development GO:0007519 IEP     axo-dendritic transport GO:0008088 IEP     RNA splicing GO:0008380 IEA     response to xenobiotic stimulus GO:0009410 IEP     response to nickel cation GO:0010045 IEP     positive regulation of gene expression GO:0010628 IMP     negative regulation of cardiac muscle cell apoptotic process GO:0010667 IMP     response to activity GO:0014823 IEP     cerebellum development GO:0021549 IEP     positive regulation of cell migration GO:0030335 ISO     forebrain development GO:0030900 IEP     regulation of protein stability GO:0031647 ISO     response to estradiol GO:0032355 IEP     response to progesterone GO:0032570 IEP     protein-containing complex disassembly GO:0032984 IMP     cellular response to heat GO:0034605 IEP     protein refolding GO:0042026 IBA     protein refolding GO:0042026 ISO     protein refolding GO:0042026 ISS     response to starvation GO:0042594 IEP     positive regulation of catalytic activity GO:0043085 IMP     protein transmembrane import into intracellular organelle GO:0044743 IEP     modulation by host of viral process GO:0044788 ISO     positive regulation by host of viral genome replication GO:0044829 IEA     positive regulation by host of viral genome replication GO:0044829 ISO     estrous cycle GO:0044849 IEP     response to ethanol GO:0045471 IEP     positive regulation of proteolysis GO:0045862 IDA     negative regulation of DNA-templated transcription GO:0045892 ISO     negative regulation of DNA-templated transcription GO:0045892 ISS     ATP metabolic process GO:0046034 ISO     protein autophosphorylation GO:0046777 IDA     positive regulation of mRNA splicing, via spliceosome GO:0048026 IEA     positive regulation of mRNA splicing, via spliceosome GO:0048026 ISO     positive regulation of phagocytosis GO:0050766 IMP     chaperone cofactor-dependent protein refolding GO:0051085 IBA     chaperone cofactor-dependent protein refolding GO:0051085 ISO     regulation of cell cycle GO:0051726 IEA     regulation of cell cycle GO:0051726 ISO     chaperone-mediated protein folding GO:0061077 IDA     chaperone-mediated protein folding GO:0061077 ISO     regulation of protein complex stability GO:0061635 IDA     chaperone-mediated autophagy GO:0061684 IDA     chaperone-mediated autophagy GO:0061684 IGI     late endosomal microautophagy GO:0061738 IEA     late endosomal microautophagy GO:0061738 ISO     protein targeting to lysosome involved in chaperone-mediated autophagy GO:0061740 ISO     protein targeting to lysosome involved in chaperone-mediated autophagy GO:0061740 ISS     cellular response to hydrogen peroxide GO:0070301 IEP     cellular response to cadmium ion GO:0071276 IEP     clathrin coat disassembly GO:0072318 IBA     clathrin coat disassembly GO:0072318 IDA     clathrin coat disassembly GO:0072318 IEA     clathrin coat disassembly GO:0072318 ISO     clathrin coat disassembly GO:0072318 ISO     positive regulation of lysosomal membrane permeability GO:0097214 IMP     maintenance of postsynaptic specialization structure GO:0098880 EXP     maintenance of postsynaptic specialization structure GO:0098880 IDA     maintenance of postsynaptic specialization structure GO:0098880 IMP     regulation of postsynapse organization GO:0099175 IEA     regulation of postsynapse organization GO:0099175 ISO     negative regulation of NLRP3 inflammasome complex assembly GO:1900226 ISO     negative regulation of supramolecular fiber organization GO:1902904 ISO     positive regulation of protein refolding GO:1904592 IDA     chaperone-mediated autophagy translocation complex disassembly GO:1904764 IDA     slow axonal transport GO:1990832 IEP     response to odorant GO:1990834 IEP Subcellular Localization     Prp19 complex GO:0000974 ISO     Prp19 complex GO:0000974 ISS     photoreceptor inner segment GO:0001917 IDA     extracellular space GO:0005615 ISO     nucleus GO:0005634 IBA     nucleus GO:0005634 ISO     nucleus GO:0005634 ISS     spliceosomal complex GO:0005681 IEA     spliceosomal complex GO:0005681 ISO     nucleolus GO:0005730 IEA     cytoplasm GO:0005737 IBA     cytoplasm GO:0005737 ISO     lysosomal membrane GO:0005765 IDA     lysosomal membrane GO:0005765 ISO     late endosome GO:0005770 IEA     late endosome GO:0005770 ISO     autophagosome GO:0005776 IDA     cytosol GO:0005829 IBA     cytosol GO:0005829 ISO     cytosol GO:0005829 TAS     microtubule GO:0005874 IDA     intermediate filament GO:0005882 IDA     plasma membrane GO:0005886 IBA     synaptic vesicle GO:0008021 IDA     cell surface GO:0009986 IDA     postsynaptic density GO:0014069 IDA     postsynaptic density GO:0014069 IDA     axon GO:0030424 IDA     dendrite GO:0030425 IDA     asymmetric synapse GO:0032279 IDA     protein-containing complex GO:0032991 IDA     melanosome GO:0042470 IEA     neuronal cell body GO:0043025 IDA     terminal bouton GO:0043195 HDA     terminal bouton GO:0043195 IDA     dendritic spine GO:0043197 IDA     dendritic shaft GO:0043198 IDA     lysosomal lumen GO:0043202 TAS     perikaryon GO:0043204 IDA     neuron spine GO:0044309 IDA     perinuclear region of cytoplasm GO:0048471 IDA     perinuclear region of cytoplasm GO:0048471 IEA     perinuclear region of cytoplasm GO:0048471 ISO     extracellular exosome GO:0070062 IEA     extracellular exosome GO:0070062 ISO     photoreceptor ribbon synapse GO:0098684 IEA     photoreceptor ribbon synapse GO:0098684 ISO     glycinergic synapse GO:0098690 EXP     glycinergic synapse GO:0098690 IDA     glycinergic synapse GO:0098690 IEA     glycinergic synapse GO:0098690 IMP     glycinergic synapse GO:0098690 ISO     presynapse GO:0098793 IDA     presynapse GO:0098793 IEA     presynapse GO:0098793 ISO     postsynapse GO:0098794 IDA     glutamatergic synapse GO:0098978 IDA     glutamatergic synapse GO:0098978 IEA     glutamatergic synapse GO:0098978 ISO     postsynaptic specialization membrane GO:0099634 IEA     postsynaptic specialization membrane GO:0099634 ISO     protein folding chaperone complex GO:0101031 ISO     lysosomal matrix GO:1990836 IDA     ribonucleoprotein complex GO:1990904 ISO     ribonucleoprotein complex GO:1990904 ISS