Gene description for TENM4
Gene name teneurin transmembrane protein 4
Gene symbol TENM4
Other names/aliases Doc4
ODZ4
TNM4
Ten-M4
Species Homo sapiens
 Database cross references - TENM4
ExoCarta ExoCarta_26011
Entrez Gene 26011
HGNC 29945
MIM 610084
UniProt Q6N022  
 TENM4 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for TENM4
Molecular Function
    protein homodimerization activity GO:0042803 ISS
Biological Process
    positive regulation of gastrulation GO:2000543 ISS
    gastrulation with mouth forming second GO:0001702 IEA
    neuron development GO:0048666 IEA
    positive regulation of oligodendrocyte differentiation GO:0048714 ISS
    central nervous system myelin formation GO:0032289 ISS
    signal transduction GO:0007165 IEA
    cardiac muscle cell proliferation GO:0060038 IEA
    self proteolysis GO:0097264 IEA
    cardiac cell fate specification GO:0060912 IEA
    positive regulation of myelination GO:0031643 ISS
Subcellular Localization
    cytoplasm GO:0005737 ISS
    neuron projection GO:0043005 ISS
    integral component of plasma membrane GO:0005887 IEA
    nucleus GO:0005634 ISS
 Experiment description of studies that identified TENM4 in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for TENM4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which TENM4 is involved
No pathways found





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