Gene description for HSP90AA1
Gene name heat shock protein 90kDa alpha (cytosolic), class A member 1
Gene symbol HSP90AA1
Other names/aliases HSPCA
Species Bos taurus
 Database cross references - HSP90AA1
ExoCarta ExoCarta_281832
Entrez Gene 281832
UniProt Q76LV2  
 HSP90AA1 identified in exosomes derived from the following tissue/cell type
Milk 23459212    
Serum 19327352    
 Gene ontology annotations for HSP90AA1
Molecular Function
    poly(A) RNA binding GO:0044822 IEA
    nitric-oxide synthase regulator activity GO:0030235 ISS
    protein binding GO:0005515 IPI
    protein homodimerization activity GO:0042803 ISS
    MHC class II protein complex binding GO:0023026 IEA
    ATP binding GO:0005524 IEA
    ATPase activity GO:0016887 IEA
    TPR domain binding GO:0030911 ISS
    unfolded protein binding GO:0051082 IEA
Biological Process
    protein folding GO:0006457 IEA
    response to stress GO:0006950 IEA
    regulation of catalytic activity GO:0050790 IEA
    chaperone-mediated protein complex assembly GO:0051131 IEA
    positive regulation of nitric oxide biosynthetic process GO:0045429 ISS
    protein import into mitochondrial outer membrane GO:0045040 IEA
Subcellular Localization
    extracellular exosome GO:0070062 IEA
    melanosome GO:0042470 IEA
    cytoplasm GO:0005737 ISS
    plasma membrane GO:0005886 IEA
    mitochondrion GO:0005739 IEA
    nucleoplasm GO:0005654 IEA
    extracellular region GO:0005576 ISS
 Experiment description of studies that identified HSP90AA1 in exosomes
1
Experiment ID 213
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23459212    
Organism Bos taurus
Experiment description Bovine milk proteome: Quantitative changes in normal milk exosomes, milk fat globule membranes and whey proteomes resulting from Staphylococcus aureus mastitis.
Authors Reinhardt TA, Sacco RE, Nonnecke BJ, Lippolis JD.
Journal name J Proteomics
Publication year 2013
Sample Milk
Sample name Staphylococcus aureus-infected-Milk
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Filtration
Sucrose density gradient
FACS
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 187
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19327352    
Organism Bos taurus
Experiment description Anchorage-independent growth of breast carcinoma cells is mediated by serum exosomes.
Authors Ochieng J, Pratap S, Khatua AK, Sakwe AM.
Journal name Exp Cell Res
Publication year 2009
Sample Serum
Sample name Normal - Fetal bovine serum
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for HSP90AA1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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