Gene description for CRB2
Gene name crumbs family member 2
Gene symbol CRB2
Other names/aliases FSGS9
Species Homo sapiens
 Database cross references - CRB2
ExoCarta ExoCarta_286204
Entrez Gene 286204
HGNC 18688
MIM 609720
UniProt Q5IJ48  
 CRB2 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for CRB2
Molecular Function
    calcium ion binding GO:0005509 IEA
    enzyme binding GO:0019899 IMP
    aspartic-type endopeptidase inhibitor activity GO:0019828 IMP
Biological Process
    mesoderm formation GO:0001707 ISS
    maintenance of epithelial cell apical/basal polarity GO:0045199 ISS
    positive regulation of BMP signaling pathway GO:0030513 ISS
    somitogenesis GO:0001756 ISS
    cardiovascular system development GO:0072358 ISS
    negative regulation of endopeptidase activity GO:0010951 IMP
    notochord formation GO:0014028 ISS
    positive regulation of epithelial to mesenchymal transition GO:0010718 ISS
Subcellular Localization
    membrane raft GO:0045121 IC
    protein complex GO:0043234 IDA
    extracellular exosome GO:0070062 IDA
    plasma membrane GO:0005886 IEA
    integral component of membrane GO:0016021 IEA
 Experiment description of studies that identified CRB2 in exosomes
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for CRB2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CTTN 2017
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which CRB2 is involved
No pathways found

Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here