Gene description for CRB2
Gene name crumbs family member 2
Gene symbol CRB2
Other names/aliases FSGS9
VMCKD
Species Homo sapiens
 Database cross references - CRB2
ExoCarta ExoCarta_286204
Vesiclepedia VP_286204
Entrez Gene 286204
HGNC 18688
MIM 609720
UniProt Q5IJ48  
 CRB2 identified in sEVs derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for CRB2
Molecular Function
    calcium ion binding GO:0005509 IEA
    protein binding GO:0005515 IPI
    aspartic-type endopeptidase inhibitor activity GO:0019828 IMP
    protein-containing complex binding GO:0044877 IMP
Biological Process
    mesoderm formation GO:0001707 ISS
    somitogenesis GO:0001756 ISS
    retina homeostasis GO:0001895 ISS
    heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 IBA
    visual perception GO:0007601 IEA
    regulation of gastrulation GO:0010470 ISS
    positive regulation of epithelial to mesenchymal transition GO:0010718 ISS
    negative regulation of endopeptidase activity GO:0010951 IMP
    notochord formation GO:0014028 ISS
    establishment of cell polarity GO:0030010 ISS
    positive regulation of BMP signaling pathway GO:0030513 ISS
    establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 IBA
    establishment or maintenance of epithelial cell apical/basal polarity GO:0045197 NAS
    maintenance of epithelial cell apical/basal polarity GO:0045199 ISS
    photoreceptor cell maintenance GO:0045494 ISS
    retinal cone cell development GO:0046549 ISS
    ingression involved in gastrulation with mouth forming second GO:0055111 ISS
    circulatory system development GO:0072359 ISS
Subcellular Localization
    cytoplasm GO:0005737 IEA
    plasma membrane GO:0005886 IBA
    apical plasma membrane GO:0016324 ISS
    apical plasma membrane GO:0016324 NAS
    apicolateral plasma membrane GO:0016327 IEA
    protein-containing complex GO:0032991 IBA
    protein-containing complex GO:0032991 IDA
    subapical complex GO:0035003 IEA
    apical junction complex GO:0043296 NAS
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified CRB2 in sEVs
1
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for CRB2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CTTN 2017
Affinity Capture-Western Homo sapiens
2 HIST1H4A 8359
Co-crystal Structure Homo sapiens
View the network image/svg+xml
 Pathways in which CRB2 is involved
No pathways found





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