Gene description for Trxr-1
Gene name Thioredoxin reductase-1
Gene symbol Trxr-1
Other names/aliases 2151
CG2151
DTR
Dm-TrxR
DmTR
DmTrx
DmTrxR
DmTrxR-1
DmelCG2151
GR
Gr
TH
TRR
Trx
TrxR
TrxR-1
Trxr1
anon-WO03040301.185
anon-WO03040301.187
dTrxR
dmtrxr-1
gr
l(1)G0154
l(1)G0379
l(1)G0477
l(1)G0481
trxr-1
Species Drosophila melanogaster
 Database cross references - Trxr-1
ExoCarta ExoCarta_31760
Vesiclepedia VP_31760
Entrez Gene 31760
UniProt P91938  
 Trxr-1 identified in exosomes derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for Trxr-1
Molecular Function
    glutathione-disulfide reductase (NADPH) activity GO:0004362 IDA
    thioredoxin-disulfide reductase (NADPH) activity GO:0004791 IDA
    antioxidant activity GO:0016209 IDA
    antioxidant activity GO:0016209 NAS
    protein homodimerization activity GO:0042803 IDA
Biological Process
    determination of adult lifespan GO:0008340 TAS
    cell redox homeostasis GO:0045454 IMP
Subcellular Localization
    cytoplasm GO:0005737 IDA
    mitochondrion GO:0005739 IDA
    cytosol GO:0005829 HDA
 Experiment description of studies that identified Trxr-1 in exosomes
1
Experiment ID 202
MISEV standards
✔
IEM
Biophysical techniques
✔
TSG10|RAB35|FLOT2
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors "Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP."
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Trxr-1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CG14715  
Affinity Capture-MS Drosophila melanogaster
2 awd  
Affinity Capture-MS Drosophila melanogaster
3 CG10638  
Affinity Capture-MS Drosophila melanogaster
4 Df31  
Affinity Capture-MS Drosophila melanogaster
5 cl  
Two-hybrid Drosophila melanogaster
6 Nlp  
Affinity Capture-MS Drosophila melanogaster
7 Trxr-2  
Affinity Capture-MS Drosophila melanogaster
8 pUf68  
Two-hybrid Drosophila melanogaster
9 Crc  
Affinity Capture-MS Drosophila melanogaster
10 Trx-2  
Affinity Capture-MS Drosophila melanogaster
11 GstO3 38972
Affinity Capture-MS Drosophila melanogaster
12 Chd64  
Affinity Capture-MS Drosophila melanogaster
13 Gos28  
Two-hybrid Drosophila melanogaster
14 CG14958  
Two-hybrid Drosophila melanogaster
15 Ho  
Affinity Capture-MS Drosophila melanogaster
16 CG2862  
Affinity Capture-MS Drosophila melanogaster
17 Ntf-2  
Affinity Capture-MS Drosophila melanogaster
18 CG4570  
Affinity Capture-MS Drosophila melanogaster
19 CG11349  
Two-hybrid Drosophila melanogaster
20 regucalcin  
Affinity Capture-MS Drosophila melanogaster
21 Mdh2  
Affinity Capture-MS Drosophila melanogaster
22 Sec22  
Two-hybrid Drosophila melanogaster
23 Sod 39251
Affinity Capture-MS Drosophila melanogaster
24 Tango2  
Affinity Capture-MS Drosophila melanogaster
25 CG2852  
Affinity Capture-MS Drosophila melanogaster
26 CG32718  
Two-hybrid Drosophila melanogaster
27 CG42565  
Two-hybrid Drosophila melanogaster
28 Eno  
Affinity Capture-MS Drosophila melanogaster
29 CG2611  
Two-hybrid Drosophila melanogaster
30 Syx4  
Two-hybrid Drosophila melanogaster
31 Fkbp14  
Affinity Capture-MS Drosophila melanogaster
32 Pdi  
Affinity Capture-MS Drosophila melanogaster
33 CG8036 41027
Affinity Capture-MS Drosophila melanogaster
34 AnxB10  
Affinity Capture-MS Drosophila melanogaster
35 LpR1  
Two-hybrid Drosophila melanogaster
36 CG1275 38286
Two-hybrid Drosophila melanogaster
37 Moe  
Affinity Capture-MS Drosophila melanogaster
38 CG6084  
Affinity Capture-MS Drosophila melanogaster
39 Prx2540-2 36098
Affinity Capture-MS Drosophila melanogaster
40 Pgd 31185
Affinity Capture-MS Drosophila melanogaster
View the network image/svg+xml



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