Gene description for Trxr-1
Gene name Thioredoxin reductase-1
Gene symbol Trxr-1
Other names/aliases 2151
CG2151
DTR
Dm-TrxR
DmTR
DmTrx
DmTrxR
DmTrxR-1
DmelCG2151
GR
Gr
TH
TRR
Trx
TrxR
TrxR-1
Trxr1
anon-WO03040301.185
anon-WO03040301.187
dTrxR
dmtrxr-1
gr
l(1)G0154
l(1)G0379
l(1)G0477
l(1)G0481
trxr-1
Species Drosophila melanogaster
 Database cross references - Trxr-1
ExoCarta ExoCarta_31760
Entrez Gene 31760
UniProt P91938  
 Trxr-1 identified in exosomes derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for Trxr-1
Molecular Function
    glutathione-disulfide reductase activity GO:0004362 NAS
    flavin adenine dinucleotide binding GO:0050660 IEA
    thioredoxin-disulfide reductase activity GO:0004791 ISS
    protein homodimerization activity GO:0042803 IDA
    antioxidant activity GO:0016209 NAS
Biological Process
    oxidation-reduction process GO:0055114 IEA
    cell redox homeostasis GO:0045454 IMP
    determination of adult lifespan GO:0008340 TAS
    neurogenesis GO:0022008 IMP
    cellular response to DNA damage stimulus GO:0006974 IMP
    response to hypoxia GO:0001666 IMP
Subcellular Localization
    cytoplasm GO:0005737 NAS
    mitochondrion GO:0005739 IDA
    microtubule associated complex GO:0005875 IDA
    cytosol GO:0005829 IDA
 Experiment description of studies that identified Trxr-1 in exosomes
1
Experiment ID 202
ISEV standards
IEM
EV Biophysical techniques
TSG10|RAB35
EV Cytosolic markers
FLOT2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP.
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Trxr-1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Trxr-1 is involved
No pathways found





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