Gene description for Pgd
Gene name Phosphogluconate dehydrogenase
Gene symbol Pgd
Other names/aliases 6-PGD
6-Pgd
6-pgd
6PGD
6PGDH
6Pgd
6Pgdh
6pgdh
A7
CG3724
DmelCG3724
EG:87B1.4
N1
PGD
Pdg
l(1)2Dc
l(1)2De
l(1)A7
l(1)G0385
l(1)N1
l(1)N3[90]
l(1)Pgd
l(1)Pgd-A
l35
pgd
Species Drosophila melanogaster
 Database cross references - Pgd
ExoCarta ExoCarta_31185
Entrez Gene 31185
UniProt P41572  
 Pgd identified in exosomes derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for Pgd
Molecular Function
    AMP-activated protein kinase activity GO:0004679 IEA
    NADP binding GO:0050661 IEA
    phosphogluconate dehydrogenase (decarboxylating) activity GO:0004616 NAS
Biological Process
    activation of MAPK activity GO:0000187 IEA
    pentose-phosphate shunt GO:0006098 NAS
    oxidation-reduction process GO:0055114 IEA
Subcellular Localization
    AMP-activated protein kinase complex GO:0031588 IEA
 Experiment description of studies that identified Pgd in exosomes
1
Experiment ID 202
ISEV standards
✔
IEM
EV Biophysical techniques
✔
TSG10|RAB35
EV Cytosolic markers
✔
FLOT2
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP.
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Pgd
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Pgd is involved
PathwayEvidenceSource
Pentose phosphate pathway (hexose monophosphate shunt) IEA Reactome





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