Gene description for Pgd
Gene name Phosphogluconate dehydrogenase
Gene symbol Pgd
Other names/aliases 6-PGD
6-Pgd
6-pgd
6PGD
6PGDH
6Pgd
6Pgdh
6pgdh
A7
CG3724
DmelCG3724
EG:87B1.4
N1
PGD
Pdg
l(1)2Dc
l(1)2De
l(1)A7
l(1)G0385
l(1)N1
l(1)N3[90]
l(1)Pgd
l(1)Pgd-A
l35
pgd
Species Drosophila melanogaster
 Database cross references - Pgd
ExoCarta ExoCarta_31185
Vesiclepedia VP_31185
Entrez Gene 31185
UniProt P41572  
 Pgd identified in sEVs derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for Pgd
Molecular Function
    phosphogluconate dehydrogenase (decarboxylating) activity GO:0004616 IDA
    phosphogluconate dehydrogenase (decarboxylating) activity GO:0004616 IMP
Biological Process
    pentose-phosphate shunt, oxidative branch GO:0009051 IMP
    glucose homeostasis GO:0042593 IMP
 Experiment description of studies that identified Pgd in sEVs
1
Experiment ID 202
MISEV standards
✔
IEM
Biophysical techniques
✔
TSG10|RAB35|FLOT2
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors "Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP."
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Pgd
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CG14715  
Affinity Capture-MS Drosophila melanogaster
2 Inos 35671
Affinity Capture-MS Drosophila melanogaster
3 awd  
Affinity Capture-MS Drosophila melanogaster
4 CG10638  
Affinity Capture-MS Drosophila melanogaster
5 Sh3beta 38820
Affinity Capture-MS Drosophila melanogaster
6 CG15818  
Affinity Capture-MS Drosophila melanogaster
7 Trxr-1 31760
Affinity Capture-MS Drosophila melanogaster
8 CG17829  
Two-hybrid Drosophila melanogaster
9 Nlp  
Affinity Capture-MS Drosophila melanogaster
10 CG1707  
Affinity Capture-MS Drosophila melanogaster
11 Uch 33397
Affinity Capture-MS Drosophila melanogaster
12 smt3  
Affinity Capture-MS Drosophila melanogaster
13 Crc  
Affinity Capture-MS Drosophila melanogaster
14 Chd64  
Affinity Capture-MS Drosophila melanogaster
15 Ald  
Affinity Capture-MS Drosophila melanogaster
16 GstO3 38972
Affinity Capture-MS Drosophila melanogaster
17 CG2862  
Affinity Capture-MS Drosophila melanogaster
18 regucalcin  
Affinity Capture-MS Drosophila melanogaster
19 PHDP  
Affinity Capture-MS Drosophila melanogaster
20 Mdh2  
Affinity Capture-MS Drosophila melanogaster
21 CG2852  
Affinity Capture-MS Drosophila melanogaster
22 CG10721  
Two-hybrid Drosophila melanogaster
23 Eno  
Affinity Capture-MS Drosophila melanogaster
24 PCNA  
Affinity Capture-MS Drosophila melanogaster
25 Df31  
Affinity Capture-MS Drosophila melanogaster
26 Fkbp14  
Affinity Capture-MS Drosophila melanogaster
27 Pdi  
Affinity Capture-MS Drosophila melanogaster
28 EndoGI 34953
Affinity Capture-MS Drosophila melanogaster
29 CG6084  
Affinity Capture-MS Drosophila melanogaster
30 AnxB10  
Affinity Capture-MS Drosophila melanogaster
31 Clic 32349
Affinity Capture-MS Drosophila melanogaster
32 PHGPx 38413
Affinity Capture-MS Drosophila melanogaster
33 Moe  
Affinity Capture-MS Drosophila melanogaster
34 Prx2540-2 36098
Affinity Capture-MS Drosophila melanogaster
View the network image/svg+xml
 Pathways in which Pgd is involved
PathwayEvidenceSource
Metabolism IEA Reactome
Metabolism of carbohydrates IEA Reactome
Pentose phosphate pathway IEA Reactome





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