Gene description for Uch
Gene name Ubiquitin carboxy-terminal hydrolase
Gene symbol Uch
Other names/aliases CG4265
DmelCG4265
P35122
UBL
UCH
UCH-D
UCH-D19
Uch-D
dUch
uch
uch-D
Species Drosophila melanogaster
 Database cross references - Uch
ExoCarta ExoCarta_33397
Vesiclepedia VP_33397
Entrez Gene 33397
UniProt P35122  
 Uch identified in exosomes derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for Uch
Molecular Function
    cysteine-type deubiquitinase activity GO:0004843 IDA
    cysteine-type deubiquitinase activity GO:0004843 IMP
Biological Process
    positive regulation of glycolytic process GO:0045821 IGI
 Experiment description of studies that identified Uch in exosomes
1
Experiment ID 202
MISEV standards
✔
IEM
Biophysical techniques
✔
TSG10|RAB35|FLOT2
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors "Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP."
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Uch
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CG14715  
Affinity Capture-MS Drosophila melanogaster
2 AnxB9  
Affinity Capture-MS Drosophila melanogaster
3 Inos 35671
Affinity Capture-MS Drosophila melanogaster
4 awd  
Affinity Capture-MS Drosophila melanogaster
5 GstE6  
Affinity Capture-MS Drosophila melanogaster
6 RhoGDI  
Affinity Capture-MS Drosophila melanogaster
7 Fim 32721
Affinity Capture-MS Drosophila melanogaster
8 Sh3beta 38820
Affinity Capture-MS Drosophila melanogaster
9 CG13887  
Affinity Capture-MS Drosophila melanogaster
10 Prosalpha1 45780
Affinity Capture-MS Drosophila melanogaster
11 Crc  
Affinity Capture-MS Drosophila melanogaster
12 CG1707  
Affinity Capture-MS Drosophila melanogaster
13 SP2637  
Affinity Capture-MS Drosophila melanogaster
14 smt3  
Affinity Capture-MS Drosophila melanogaster
15 CG7911  
Affinity Capture-MS Drosophila melanogaster
16 Pgk 33461
Affinity Capture-MS Drosophila melanogaster
17 Nlp  
Affinity Capture-MS Drosophila melanogaster
18 Chd64  
Affinity Capture-MS Drosophila melanogaster
19 UBA52 7311
Biochemical Activity Homo sapiens
20 EndoGI 34953
Affinity Capture-MS Drosophila melanogaster
21 Eb1  
Affinity Capture-MS Drosophila melanogaster
22 Ald  
Affinity Capture-MS Drosophila melanogaster
23 GstO3 38972
Affinity Capture-MS Drosophila melanogaster
24 CG2862  
Affinity Capture-MS Drosophila melanogaster
25 CG10638  
Affinity Capture-MS Drosophila melanogaster
26 GstT1  
Affinity Capture-MS Drosophila melanogaster
27 regucalcin  
Affinity Capture-MS Drosophila melanogaster
28 scf  
Affinity Capture-MS Drosophila melanogaster
29 CG7430  
Affinity Capture-MS Drosophila melanogaster
30 CG6180 34683
Affinity Capture-MS Drosophila melanogaster
31 Mdh2  
Affinity Capture-MS Drosophila melanogaster
32 Trx-2  
Affinity Capture-MS Drosophila melanogaster
33 scu  
Affinity Capture-MS Drosophila melanogaster
34 CG2852  
Affinity Capture-MS Drosophila melanogaster
35 FK506-bp2  
Affinity Capture-MS Drosophila melanogaster
36 sel  
Affinity Capture-MS Drosophila melanogaster
37 CG10863  
Affinity Capture-MS Drosophila melanogaster
38 CG5174 37117
Affinity Capture-MS Drosophila melanogaster
39 Eno  
Affinity Capture-MS Drosophila melanogaster
40 Hop 33202
Affinity Capture-MS Drosophila melanogaster
41 cib 31359
Affinity Capture-MS Drosophila melanogaster
42 CG4598  
Affinity Capture-MS Drosophila melanogaster
43 CTPsyn  
Proximity Label-MS Drosophila melanogaster
44 PCNA  
Affinity Capture-MS Drosophila melanogaster
45 yip2  
Affinity Capture-MS Drosophila melanogaster
46 Fkbp14  
Affinity Capture-MS Drosophila melanogaster
47 Pdi  
Affinity Capture-MS Drosophila melanogaster
48 Df31  
Affinity Capture-MS Drosophila melanogaster
49 CG42797  
Two-hybrid Drosophila melanogaster
50 chic  
Affinity Capture-MS Drosophila melanogaster
51 eEF1delta  
Affinity Capture-MS Drosophila melanogaster
52 Akap200  
Affinity Capture-MS Drosophila melanogaster
53 AnxB10  
Affinity Capture-MS Drosophila melanogaster
54 CG8036 41027
Affinity Capture-MS Drosophila melanogaster
55 PHGPx 38413
Affinity Capture-MS Drosophila melanogaster
56 TER94  
Affinity Capture-MS Drosophila melanogaster
57 Nacalpha  
Affinity Capture-MS Drosophila melanogaster
58 Moe  
Affinity Capture-MS Drosophila melanogaster
59 CG6084  
Affinity Capture-MS Drosophila melanogaster
60 Prx2540-2 36098
Affinity Capture-MS Drosophila melanogaster
61 Pgd 31185
Affinity Capture-MS Drosophila melanogaster
62 Sod2  
Affinity Capture-MS Drosophila melanogaster
63 fax  
Affinity Capture-MS Drosophila melanogaster
64 Gdi 34264
Affinity Capture-MS Drosophila melanogaster
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