Gene description for Uch
Gene name Ubiquitin carboxy-terminal hydrolase
Gene symbol Uch
Other names/aliases CG4265
DmelCG4265
P35122
UBL
UCH
UCH-D
UCH-D19
Uch-D
dUch
uch
uch-D
Species Drosophila melanogaster
 Database cross references - Uch
ExoCarta ExoCarta_33397
Entrez Gene 33397
UniProt P35122  
 Uch identified in exosomes derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for Uch
Molecular Function
    ubiquitin-specific protease activity GO:0004843 IDA
Biological Process
    ubiquitin-dependent protein catabolic process GO:0006511 IEA
    protein deubiquitination GO:0016579 IDA
Subcellular Localization
    microtubule associated complex GO:0005875 IDA
 Experiment description of studies that identified Uch in exosomes
1
Experiment ID 202
ISEV standards
IEM
EV Biophysical techniques
TSG10|RAB35
EV Cytosolic markers
FLOT2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP.
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Uch
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Uch is involved
No pathways found





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