Gene description for Inos
Gene name CG11143 gene product from transcript CG11143-RA
Gene symbol Inos
Other names/aliases CG11143
DmelCG11143
INOS
bs36h12.y1
Species Drosophila melanogaster
 Database cross references - Inos
ExoCarta ExoCarta_35671
Entrez Gene 35671
UniProt O97477  
 Inos identified in exosomes derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for Inos
Molecular Function
    inositol-3-phosphate synthase activity GO:0004512 NAS
Biological Process
    phospholipid biosynthetic process GO:0008654 IEA
    inositol biosynthetic process GO:0006021 ISS
Subcellular Localization
    cytoplasm GO:0005737 ISS
 Experiment description of studies that identified Inos in exosomes
1
Experiment ID 202
ISEV standards
✔
IEM
EV Biophysical techniques
✔
TSG10|RAB35
EV Cytosolic markers
✔
FLOT2
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP.
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Inos
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Inos is involved
PathwayEvidenceSource
Synthesis of IP2, IP, and Ins in the cytosol IEA Reactome





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