Gene description for Inos
Gene name CG11143 gene product from transcript CG11143-RA
Gene symbol Inos
Other names/aliases CG11143
DmelCG11143
INOS
bs36h12.y1
Species Drosophila melanogaster
 Database cross references - Inos
ExoCarta ExoCarta_35671
Vesiclepedia VP_35671
Entrez Gene 35671
UniProt O97477  
 Inos identified in exosomes derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for Inos
Molecular Function
    inositol-3-phosphate synthase activity GO:0004512 IDA
    inositol-3-phosphate synthase activity GO:0004512 ISS
Biological Process
    inositol biosynthetic process GO:0006021 ISS
Subcellular Localization
    cytoplasm GO:0005737 ISS
 Experiment description of studies that identified Inos in exosomes
1
Experiment ID 202
MISEV standards
✔
IEM
Biophysical techniques
✔
TSG10|RAB35|FLOT2
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors "Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP."
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Inos
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CG14715  
Affinity Capture-MS Drosophila melanogaster
2 CG5355  
Affinity Capture-MS Drosophila melanogaster
3 eEF1delta  
Affinity Capture-MS Drosophila melanogaster
4 awd  
Affinity Capture-MS Drosophila melanogaster
5 CG10638  
Affinity Capture-MS Drosophila melanogaster
6 CG16817 41173
Affinity Capture-MS Drosophila melanogaster
7 RhoGDI  
Affinity Capture-MS Drosophila melanogaster
8 Fim 32721
Affinity Capture-MS Drosophila melanogaster
9 Df31  
Affinity Capture-MS Drosophila melanogaster
10 CG11807  
Affinity Capture-MS Drosophila melanogaster
11 TER94  
Affinity Capture-MS Drosophila melanogaster
12 Snx3  
Affinity Capture-MS Drosophila melanogaster
13 Nlp  
Affinity Capture-MS Drosophila melanogaster
14 Uch 33397
Affinity Capture-MS Drosophila melanogaster
15 smt3  
Affinity Capture-MS Drosophila melanogaster
16 Crc  
Affinity Capture-MS Drosophila melanogaster
17 flr 39505
Affinity Capture-MS Drosophila melanogaster
18 CG6543  
Affinity Capture-MS Drosophila melanogaster
19 CG1910  
Affinity Capture-MS Drosophila melanogaster
20 Chd64  
Affinity Capture-MS Drosophila melanogaster
21 cry  
Proximity Label-MS Drosophila melanogaster
22 Eb1  
Affinity Capture-MS Drosophila melanogaster
23 Ald  
Affinity Capture-MS Drosophila melanogaster
24 GstO3 38972
Affinity Capture-MS Drosophila melanogaster
25 CG8888  
Affinity Capture-MS Drosophila melanogaster
26 CG2862  
Affinity Capture-MS Drosophila melanogaster
27 eIF-5A  
Affinity Capture-MS Drosophila melanogaster
28 CG7430  
Affinity Capture-MS Drosophila melanogaster
29 Spindly  
Affinity Capture-MS Drosophila melanogaster
30 CG32549 32822
Affinity Capture-MS Drosophila melanogaster
31 CG8891  
Affinity Capture-MS Drosophila melanogaster
32 regucalcin  
Affinity Capture-MS Drosophila melanogaster
33 CG2852  
Affinity Capture-MS Drosophila melanogaster
34 Mdh2  
Affinity Capture-MS Drosophila melanogaster
35 scu  
Affinity Capture-MS Drosophila melanogaster
36 scf  
Affinity Capture-MS Drosophila melanogaster
37 Bacc  
Affinity Capture-MS Drosophila melanogaster
38 CG5174 37117
Affinity Capture-MS Drosophila melanogaster
39 Pgd 31185
Affinity Capture-MS Drosophila melanogaster
40 Eno  
Affinity Capture-MS Drosophila melanogaster
41 cib 31359
Affinity Capture-MS Drosophila melanogaster
42 CG4598  
Affinity Capture-MS Drosophila melanogaster
43 PCNA  
Affinity Capture-MS Drosophila melanogaster
44 yip2  
Affinity Capture-MS Drosophila melanogaster
45 Fkbp14  
Affinity Capture-MS Drosophila melanogaster
46 Pdi  
Affinity Capture-MS Drosophila melanogaster
47 Sh3beta 38820
Affinity Capture-MS Drosophila melanogaster
48 CG8036 41027
Affinity Capture-MS Drosophila melanogaster
49 fax  
Affinity Capture-MS Drosophila melanogaster
50 EndoGI 34953
Affinity Capture-MS Drosophila melanogaster
51 Akap200  
Affinity Capture-MS Drosophila melanogaster
52 AnxB10  
Affinity Capture-MS Drosophila melanogaster
53 CG6084  
Affinity Capture-MS Drosophila melanogaster
54 PHGPx 38413
Affinity Capture-MS Drosophila melanogaster
55 EF2 35422
Affinity Capture-MS Drosophila melanogaster
56 Nacalpha  
Affinity Capture-MS Drosophila melanogaster
57 Moe  
Affinity Capture-MS Drosophila melanogaster
58 FK506-bp2  
Affinity Capture-MS Drosophila melanogaster
59 Prx2540-2 36098
Affinity Capture-MS Drosophila melanogaster
60 dod  
Affinity Capture-MS Drosophila melanogaster
61 Hsc70Cb 39557
Affinity Capture-MS Drosophila melanogaster
62 chic  
Affinity Capture-MS Drosophila melanogaster
63 CG10420  
Affinity Capture-MS Drosophila melanogaster
View the network image/svg+xml
 Pathways in which Inos is involved
PathwayEvidenceSource
Inositol phosphate metabolism IEA Reactome
Metabolism IEA Reactome
Synthesis of IP2, IP, and Ins in the cytosol IEA Reactome





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