Gene description for flr
Gene name flare
Gene symbol flr
Other names/aliases AIP1
Aip1
CG10724
DmelCG10724
aip1
Species Drosophila melanogaster
 Database cross references - flr
ExoCarta ExoCarta_39505
Vesiclepedia VP_39505
Entrez Gene 39505
UniProt Q9VU68  
 flr identified in exosomes derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for flr
Biological Process
    establishment of planar polarity GO:0001736 IMP
    border follicle cell migration GO:0007298 IMP
    actin filament depolymerization GO:0030042 IMP
    regulation of actin filament polymerization GO:0030833 IMP
    regulation of actin filament depolymerization GO:0030834 IMP
    negative regulation of Arp2/3 complex-mediated actin nucleation GO:0034316 IGI
    imaginal disc-derived wing hair organization GO:0035317 IMP
    sarcomere organization GO:0045214 IMP
Subcellular Localization
    cytoskeleton GO:0005856 IDA
 Experiment description of studies that identified flr in exosomes
1
Experiment ID 202
MISEV standards
IEM
Biophysical techniques
TSG10|RAB35|FLOT2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors "Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP."
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for flr
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Crc  
Affinity Capture-MS Drosophila melanogaster
2 Inos 35671
Affinity Capture-MS Drosophila melanogaster
3 EndoGI 34953
Affinity Capture-MS Drosophila melanogaster
4 CG8204  
Two-hybrid Drosophila melanogaster
5 Act79B  
Two-hybrid Drosophila melanogaster
6 Act88F  
Two-hybrid Drosophila melanogaster
7 Moe  
Affinity Capture-MS Drosophila melanogaster
8 Hsc70Cb 39557
Affinity Capture-MS Drosophila melanogaster
9 regucalcin  
Affinity Capture-MS Drosophila melanogaster
10 CG17337  
Affinity Capture-MS Drosophila melanogaster
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