Gene description for flr
Gene name flare
Gene symbol flr
Other names/aliases AIP1
Aip1
CG10724
DmelCG10724
aip1
Species Drosophila melanogaster
 Database cross references - flr
ExoCarta ExoCarta_39505
Entrez Gene 39505
UniProt Q9VU68  
 flr identified in exosomes derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for flr
Molecular Function
    actin binding GO:0003779 ISS
Biological Process
    imaginal disc-derived wing hair organization GO:0035317 IMP
    phagocytosis GO:0006909 IMP
    actin filament depolymerization GO:0030042 ISS
    border follicle cell migration GO:0007298 IMP
    actin polymerization or depolymerization GO:0008154 ISS
    sarcomere organization GO:0045214 IMP
    regulation of actin filament polymerization GO:0030833 IMP
    negative regulation of Arp2/3 complex-mediated actin nucleation GO:0034316 IGI
 Experiment description of studies that identified flr in exosomes
1
Experiment ID 202
ISEV standards
✔
IEM
EV Biophysical techniques
✔
TSG10|RAB35
EV Cytosolic markers
✔
FLOT2
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP.
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for flr
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which flr is involved
PathwayEvidenceSource
Platelet degranulation IEA Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here