Gene description for Hsc70Cb
Gene name CG6603 gene product from transcript CG6603-RI
Gene symbol Hsc70Cb
Other names/aliases 0041/12
0318/20
1342/17
1348/02
1485/13
BEST:LD32772
CG6603
DmelCG6603
HSC-70
HSC70
HSC70cb
HSP110
HSP110-1
Hsc70
LD32772
anon-WO0118547.302
dHsp110
hsc70Cb
hsc70cb
l(3)00082
l(3)07621
l(3)134217
l(3)148513
l(3)70Ca
l(3)70Cb
l(3)S134217
l(3)S134802
l(3)S148513
Species Drosophila melanogaster
 Database cross references - Hsc70Cb
ExoCarta ExoCarta_39557
Vesiclepedia VP_39557
Entrez Gene 39557
 Hsc70Cb identified in exosomes derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for Hsc70Cb
Molecular Function
    ATP hydrolysis activity GO:0016887 NAS
    denatured protein binding GO:0031249 ISS
Biological Process
    cellular response to heat GO:0034605 ISS
Subcellular Localization
    nucleus GO:0005634 HDA
    cytoplasm GO:0005737 HDA
    cytosol GO:0005829 HDA
 Experiment description of studies that identified Hsc70Cb in exosomes
1
Experiment ID 202
MISEV standards
IEM
Biophysical techniques
TSG10|RAB35|FLOT2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors "Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP."
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Hsc70Cb
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CG14715  
Affinity Capture-MS Drosophila melanogaster
2 Inos 35671
Affinity Capture-MS Drosophila melanogaster
3 awd  
Affinity Capture-MS Drosophila melanogaster
4 CG10638  
Affinity Capture-MS Drosophila melanogaster
5 Sh3beta 38820
Affinity Capture-MS Drosophila melanogaster
6 Crc  
Affinity Capture-MS Drosophila melanogaster
7 flr 39505
Affinity Capture-MS Drosophila melanogaster
8 TER94  
Affinity Capture-MS Drosophila melanogaster
9 CG2862  
Affinity Capture-MS Drosophila melanogaster
10 regucalcin  
Affinity Capture-MS Drosophila melanogaster
11 CG17337  
Affinity Capture-MS Drosophila melanogaster
12 Eno  
Affinity Capture-MS Drosophila melanogaster
13 Hop 33202
Affinity Capture-MS Drosophila melanogaster
14 cib 31359
Affinity Capture-MS Drosophila melanogaster
15 CTPsyn  
Proximity Label-MS Drosophila melanogaster
16 yip2  
Affinity Capture-MS Drosophila melanogaster
17 Fkbp14  
Affinity Capture-MS Drosophila melanogaster
18 Df31  
Affinity Capture-MS Drosophila melanogaster
19 CG8036 41027
Affinity Capture-MS Drosophila melanogaster
20 EndoGI 34953
Affinity Capture-MS Drosophila melanogaster
21 Akap200  
Affinity Capture-MS Drosophila melanogaster
22 AnxB10  
Affinity Capture-MS Drosophila melanogaster
23 Chd64  
Affinity Capture-MS Drosophila melanogaster
24 Nacalpha  
Affinity Capture-MS Drosophila melanogaster
25 Moe  
Affinity Capture-MS Drosophila melanogaster
26 Prx2540-2 36098
Affinity Capture-MS Drosophila melanogaster
27 Rpn10  
Affinity Capture-MS Drosophila melanogaster
28 Gdi 34264
Affinity Capture-MS Drosophila melanogaster
View the network image/svg+xml
 Pathways in which Hsc70Cb is involved
No pathways found





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