Gene description for EndoGI
Gene name Endonuclease G inhibitor
Gene symbol EndoGI
Other names/aliases BG:DS07473.2
Species Drosophila melanogaster
 Database cross references - EndoGI
ExoCarta ExoCarta_34953
Entrez Gene 34953
 EndoGI identified in exosomes derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for EndoGI
Molecular Function
    telomeric DNA binding GO:0042162 IEA
    hydrolase activity, acting on acid anhydrides GO:0016817 IEA
    damaged DNA binding GO:0003684 IEA
    ribonuclease inhibitor activity GO:0008428 IDA
Biological Process
    telomere maintenance GO:0000723 IEA
    double-strand break repair via nonhomologous end joining GO:0006303 IEA
    negative regulation of endoribonuclease activity GO:0060702 IDA
    positive regulation of Notch signaling pathway GO:0045747 IMP
    DNA recombination GO:0006310 IEA
    motor neuron axon guidance GO:0008045 IMP
Subcellular Localization
    nucleus GO:0005634 IDA
    Ku70:Ku80 complex GO:0043564 IEA
 Experiment description of studies that identified EndoGI in exosomes
Experiment ID 202
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP.
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for EndoGI
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which EndoGI is involved
No pathways found

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