Gene description for Clic
Gene name Chloride intracellular channel
Gene symbol Clic
Other names/aliases CG10997
DCLIC
DmCLIC
DmelCG10997
clic
l(1)G0053
l(1)G0472
Species Drosophila melanogaster
 Database cross references - Clic
ExoCarta ExoCarta_32349
Entrez Gene 32349
 Clic identified in exosomes derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for Clic
Molecular Function
    chloride channel activity GO:0005254 ISS
    calcium ion binding GO:0005509 IDA
    lipid binding GO:0008289 IDA
Biological Process
    chloride transport GO:0006821 IDA
    response to oxidative stress GO:0006979 IMP
    negative gravitaxis GO:0048060 IDA
    determination of adult lifespan GO:0008340 IMP
    response to alcohol GO:0097305 IDA
Subcellular Localization
    cytosol GO:0005829 IDA
    nucleoplasm GO:0005654 IDA
 Experiment description of studies that identified Clic in exosomes
1
Experiment ID 202
ISEV standards
IEM
EV Biophysical techniques
TSG10|RAB35
EV Cytosolic markers
FLOT2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP.
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Clic
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Clic is involved
No pathways found





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