Gene description for Clic
Gene name Chloride intracellular channel
Gene symbol Clic
Other names/aliases CG10997
DCLIC
DmCLIC
DmelCG10997
clic
l(1)G0053
l(1)G0472
Species Drosophila melanogaster
 Database cross references - Clic
ExoCarta ExoCarta_32349
Vesiclepedia VP_32349
Entrez Gene 32349
 Clic identified in exosomes derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for Clic
Molecular Function
    chloride channel activity GO:0005254 IDA
    calcium ion binding GO:0005509 IDA
    lipid binding GO:0008289 IDA
Biological Process
    chloride transport GO:0006821 IDA
    negative gravitaxis GO:0048060 IDA
    response to alcohol GO:0097305 IDA
Subcellular Localization
    nucleoplasm GO:0005654 HDA
    cytosol GO:0005829 HDA
    membrane GO:0016020 IC
    mitochondrial membrane GO:0031966 IDA
 Experiment description of studies that identified Clic in exosomes
1
Experiment ID 202
MISEV standards
IEM
Biophysical techniques
TSG10|RAB35|FLOT2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors "Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP."
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Clic
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CG10638  
Affinity Capture-MS Drosophila melanogaster
2 CG10265  
Affinity Capture-MS Drosophila melanogaster
3 CG34198  
Two-hybrid Drosophila melanogaster
4 CG1910  
Affinity Capture-MS Drosophila melanogaster
5 Synd  
Affinity Capture-MS Drosophila melanogaster
6 HIP-R 31335
Affinity Capture-MS Drosophila melanogaster
7 GstO3 38972
Affinity Capture-MS Drosophila melanogaster
8 eIF-5A  
Affinity Capture-MS Drosophila melanogaster
9 CG5568  
Affinity Capture-MS Drosophila melanogaster
10 regucalcin  
Affinity Capture-MS Drosophila melanogaster
11 Mdh2  
Affinity Capture-MS Drosophila melanogaster
12 rev7  
Two-hybrid Drosophila melanogaster
13 CG2852  
Affinity Capture-MS Drosophila melanogaster
14 Gs1  
Affinity Capture-MS Drosophila melanogaster
15 RabX1  
Affinity Capture-MS Drosophila melanogaster
16 SelD  
Affinity Capture-MS Drosophila melanogaster
17 CG31038  
Two-hybrid Drosophila melanogaster
18 CG7737  
Affinity Capture-MS Drosophila melanogaster
19 CG5044  
Affinity Capture-MS Drosophila melanogaster
20 AnxB10  
Affinity Capture-MS Drosophila melanogaster
21 PHGPx 38413
Affinity Capture-MS Drosophila melanogaster
22 r-l  
Affinity Capture-MS Drosophila melanogaster
23 Pgd 31185
Affinity Capture-MS Drosophila melanogaster
View the network image/svg+xml
 Pathways in which Clic is involved
No pathways found





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