Gene description for Tnpo3
Gene name transportin 3
Gene symbol Tnpo3
Other names/aliases 5730544L10Rik
C430013M08Rik
C81142
D6Ertd313e
Trn-SR
mKIAA4133
Species Mus musculus
 Database cross references - Tnpo3
ExoCarta ExoCarta_320938
Vesiclepedia VP_320938
Entrez Gene 320938
UniProt Q6P2B1  
 Tnpo3 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Tnpo3
Molecular Function
    small GTPase binding GO:0031267 ISO
    small GTPase binding GO:0031267 ISS
    identical protein binding GO:0042802 IEA
    identical protein binding GO:0042802 ISO
Biological Process
    protein import into nucleus GO:0006606 IBA
    protein import into nucleus GO:0006606 ISO
    protein import into nucleus GO:0006606 ISS
Subcellular Localization
    nuclear envelope GO:0005635 ISO
    nuclear envelope GO:0005635 ISS
    annulate lamellae GO:0005642 ISO
    annulate lamellae GO:0005642 ISS
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IEA
    intracellular membrane-bounded organelle GO:0043231 ISO
 Experiment description of studies that identified Tnpo3 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Tnpo3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Atxn1  
Affinity Capture-MS Mus musculus
2 Eed  
Affinity Capture-MS Mus musculus
3 Srsf3 20383
Co-fractionation Mus musculus
4 Srsf7 225027
Co-fractionation Mus musculus
5 Unk  
Affinity Capture-RNA Mus musculus
View the network image/svg+xml
 Pathways in which Tnpo3 is involved
No pathways found





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