Gene description for HOXB3
Gene name homeobox B3
Gene symbol HOXB3
Other names/aliases HOX2
HOX2G
Hox-2.7
Species Homo sapiens
 Database cross references - HOXB3
ExoCarta ExoCarta_3213
Entrez Gene 3213
HGNC 5114
MIM 142966
UniProt P14651  
 HOXB3 identified in exosomes derived from the following tissue/cell type
Squamous carcinoma cells 20124223    
 Gene ontology annotations for HOXB3
Molecular Function
    sequence-specific DNA binding transcription factor activity GO:0003700 IEA
    RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 IEA
Biological Process
    anterior/posterior pattern specification GO:0009952 IEA
    embryonic skeletal system morphogenesis GO:0048704 IEA
    face development GO:0060324 IEA
    thyroid gland development GO:0030878 IEA
    glossopharyngeal nerve morphogenesis GO:0021615 IEA
    transcription, DNA-templated GO:0006351 IEA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IEA
    regulation of neurogenesis GO:0050767 IEA
    cartilage development GO:0051216 IEA
    angiogenesis GO:0001525 IEP
    definitive hemopoiesis GO:0060216 IEA
    rhombomere development GO:0021546 IEA
    hematopoietic progenitor cell differentiation GO:0002244 IEA
Subcellular Localization
    nucleus GO:0005634 IEA
 Experiment description of studies that identified HOXB3 in exosomes
1
Experiment ID 191
ISEV standards
✘ EV Biophysical techniques
✔
Alix
EV Cytosolic markers
✔
CD81|CD9
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for HOXB3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HMGB1 3146
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which HOXB3 is involved
No pathways found





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