Gene description for HOXB3
Gene name homeobox B3
Gene symbol HOXB3
Other names/aliases HOX2
HOX2G
Hox-2.7
Species Homo sapiens
 Database cross references - HOXB3
ExoCarta ExoCarta_3213
Vesiclepedia VP_3213
Entrez Gene 3213
HGNC 5114
MIM 142966
UniProt P14651  
 HOXB3 identified in exosomes derived from the following tissue/cell type
Squamous carcinoma cells 20124223    
 Gene ontology annotations for HOXB3
Molecular Function
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IDA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 ISA
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IDA
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IEA
    angiogenesis GO:0001525 IEP
    hematopoietic progenitor cell differentiation GO:0002244 IEA
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    anterior/posterior pattern specification GO:0009952 IBA
    rhombomere development GO:0021546 IEA
    glossopharyngeal nerve morphogenesis GO:0021615 IEA
    thyroid gland development GO:0030878 IEA
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    embryonic skeletal system morphogenesis GO:0048704 IBA
    regulation of neurogenesis GO:0050767 IEA
    cartilage development GO:0051216 IEA
    definitive hemopoiesis GO:0060216 IEA
    face development GO:0060324 IEA
Subcellular Localization
    chromatin GO:0000785 ISA
    nucleus GO:0005634 IBA
    nucleoplasm GO:0005654 IDA
 Experiment description of studies that identified HOXB3 in exosomes
1
Experiment ID 191
MISEV standards
Biophysical techniques
Alix|CD81|CD9
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors "Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK."
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for HOXB3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PTX3 5806
Affinity Capture-MS Homo sapiens
2 FBLN5 10516
Affinity Capture-MS Homo sapiens
3 DPP9 91039
Affinity Capture-MS Homo sapiens
4 CREBBP  
Reconstituted Complex Homo sapiens
5 HMGB1 3146
Reconstituted Complex Homo sapiens
6 MIPEP  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here