Gene description for cpa
Gene name capping protein alpha
Gene symbol cpa
Other names/aliases CG10540
Cpa
DmelCG10540
dMiro1
miro
scrd
Species Drosophila melanogaster
 Database cross references - cpa
ExoCarta ExoCarta_37387
Entrez Gene 37387
UniProt Q9W2N0  
 cpa identified in exosomes derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for cpa
Molecular Function
    protein heterodimerization activity GO:0046982 IPI
Biological Process
    regulation of filopodium assembly GO:0051489 IMP
    actin cytoskeleton organization GO:0030036 NAS
    negative regulation of actin filament polymerization GO:0030837 IMP
    actin filament organization GO:0007015 IMP
    germarium-derived oocyte fate determination GO:0007294 IMP
    barbed-end actin filament capping GO:0051016 NAS
    negative regulation of filopodium assembly GO:0051490 IMP
    wing disc development GO:0035220 IMP
    phagocytosis GO:0006909 IMP
    regulation of lamellipodium assembly GO:0010591 IMP
    negative regulation of JNK cascade GO:0046329 IGI
    microtubule-based movement GO:0007018 ISS
    cell morphogenesis GO:0000902 IMP
Subcellular Localization
    F-actin capping protein complex GO:0008290 NAS
    microtubule associated complex GO:0005875 IDA
    dynactin complex GO:0005869 ISS
    adherens junction GO:0005912 IDA
    apical plasma membrane GO:0016324 IDA
 Experiment description of studies that identified cpa in exosomes
1
Experiment ID 202
ISEV standards
✔
IEM
EV Biophysical techniques
✔
TSG10|RAB35
EV Cytosolic markers
✔
FLOT2
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP.
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for cpa
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which cpa is involved
PathwayEvidenceSource
Factors involved in megakaryocyte development and platelet production IEA Reactome





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