ExoCarta: Gene summary

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Gene description for cpa
Gene name	capping protein alpha
Gene symbol	cpa
Other names/aliases	CG10540 Cpa DmelCG10540 dMiro1 miro scrd
Species	Drosophila melanogaster
Database cross references - cpa
ExoCarta	ExoCarta_37387
Vesiclepedia	VP_37387
Entrez Gene	37387
UniProt	Q9W2N0
cpa identified in exosomes derived from the following tissue/cell type
Drosophila S2 cells	23035643

Gene ontology annotations for cpa

Experiment description of studies that identified cpa in exosomes

Experiment ID

202

MISEV standards
✔ IEM	Biophysical techniques
✔ TSG10\|RAB35\|FLOT2	Enriched markers
✘	Negative markers
✘	Particle analysis

Identified molecule

protein

Identification method

Mass spectrometry

PubMed ID

23035643

Organism

Drosophila melanogaster

Experiment description

Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.

Authors

"Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP."

Journal name

Traffic

Publication year

2012

Sample

Drosophila S2 cells

Sample name

Normal-Drosophila S2 tub-Wg

Isolation/purification methods

Filtration
Ultracentrifugation
Sucrose density gradient

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Mass spectrometry

Protein-protein interactions for cpa

Protein Interactor

ExoCarta ID

Identification method

PubMed

Species

CG9014

Two-hybrid

Drosophila melanogaster

CG4335

Two-hybrid

Drosophila melanogaster

CG8578

Affinity Capture-MS

Drosophila melanogaster

Dmn

Affinity Capture-MS

Drosophila melanogaster

Arpc3A

Affinity Capture-MS

Drosophila melanogaster

Snr1

Two-hybrid

Drosophila melanogaster

CG14894

Proximity Label-MS

Drosophila melanogaster

Arpc4

Affinity Capture-MS

Drosophila melanogaster

CG18748

Affinity Capture-MS

Drosophila melanogaster

Arpc5

Affinity Capture-MS

Drosophila melanogaster

Swip-1

35158

Affinity Capture-MS

Drosophila melanogaster

CG1399

Affinity Capture-MS

Drosophila melanogaster

me31B

Proximity Label-MS

Drosophila melanogaster

CG15710

Two-hybrid

Drosophila melanogaster

CG14506

Two-hybrid

Drosophila melanogaster

CG14410

Two-hybrid

Drosophila melanogaster

didum

Affinity Capture-MS

Drosophila melanogaster

Arp2

Affinity Capture-MS

Drosophila melanogaster

Arpc1

Affinity Capture-MS

Drosophila melanogaster

Arpc2

Affinity Capture-MS

Drosophila melanogaster

cpb

33346

Affinity Capture-MS		Drosophila melanogaster
Two-hybrid		Drosophila melanogaster

Act57B

Affinity Capture-MS

Drosophila melanogaster

Arp3

Affinity Capture-MS

Drosophila melanogaster

AdipoR

Two-hybrid

Drosophila melanogaster

View the network

Pathways in which cpa is involved

Pathway	Evidence	Source
Asparagine N-linked glycosylation	IEA	Reactome
Cellular responses to stimuli	IEA	Reactome
Cellular responses to stress	IEA	Reactome
COPI-independent Golgi-to-ER retrograde traffic	IEA	Reactome
COPI-mediated anterograde transport	IEA	Reactome
ER to Golgi Anterograde Transport	IEA	Reactome
Factors involved in megakaryocyte development and platelet production	IEA	Reactome
Golgi-to-ER retrograde transport	IEA	Reactome
Hemostasis	IEA	Reactome
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand	IEA	Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic	IEA	Reactome
Membrane Trafficking	IEA	Reactome
Metabolism of proteins	IEA	Reactome
Post-translational protein modification	IEA	Reactome
Transport to the Golgi and subsequent modification	IEA	Reactome
Vesicle-mediated transport	IEA	Reactome

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