Gene description for cpb
Gene name capping protein beta
Gene symbol cpb
Other names/aliases CAPB_DROME
CG17158
CP
CP-beta
CPB
CapZ
Cpb
DmelCG17158
J
bnd
Species Drosophila melanogaster
 Database cross references - cpb
ExoCarta ExoCarta_33346
Entrez Gene 33346
UniProt P48603  
 cpb identified in exosomes derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for cpb
Molecular Function
    actin binding GO:0003779 ISS
    protein heterodimerization activity GO:0046982 IPI
Biological Process
    regulation of actin filament length GO:0030832 IMP
    cytoplasmic transport, nurse cell to oocyte GO:0007303 IMP
    negative regulation of filopodium assembly GO:0051490 IMP
    cell morphogenesis GO:0000902 IMP
    negative regulation of JNK cascade GO:0046329 IGI
    actin filament organization GO:0007015 IMP
    regulation of lamellipodium assembly GO:0010591 IMP
    border follicle cell migration GO:0007298 IMP
    actin cytoskeleton organization GO:0030036 IMP
    barbed-end actin filament capping GO:0051016 IMP
    wing disc development GO:0035220 IMP
    positive regulation of synaptic growth at neuromuscular junction GO:0045887 IMP
Subcellular Localization
    adherens junction GO:0005912 IDA
    cytoplasm GO:0005737 IEA
    F-actin capping protein complex GO:0008290 NAS
 Experiment description of studies that identified cpb in exosomes
1
Experiment ID 202
ISEV standards
IEM
EV Biophysical techniques
TSG10|RAB35
EV Cytosolic markers
FLOT2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP.
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for cpb
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which cpb is involved
PathwayEvidenceSource
Factors involved in megakaryocyte development and platelet production IEA Reactome





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