Gene description for cpb
Gene name capping protein beta
Gene symbol cpb
Other names/aliases CAPB_DROME
CG17158
CP
CP-beta
CPB
CapZ
Cpb
DmelCG17158
J
bnd
Species Drosophila melanogaster
 Database cross references - cpb
ExoCarta ExoCarta_33346
Vesiclepedia VP_33346
Entrez Gene 33346
UniProt P48603  
 cpb identified in exosomes derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for cpb
Molecular Function
    protein heterodimerization activity GO:0046982 IPI
Biological Process
    actin filament organization GO:0007015 IMP
    microtubule-based movement GO:0007018 IC
    border follicle cell migration GO:0007298 IMP
    ovarian nurse cell to oocyte transport GO:0007300 IMP
    regulation of lamellipodium assembly GO:0010591 IMP
    actin cytoskeleton organization GO:0030036 IMP
    regulation of actin filament length GO:0030832 IMP
    wing disc development GO:0035220 IMP
    positive regulation of synaptic assembly at neuromuscular junction GO:0045887 IMP
    negative regulation of JNK cascade GO:0046329 IGI
    barbed-end actin filament capping GO:0051016 IDA
    barbed-end actin filament capping GO:0051016 IMP
    negative regulation of filopodium assembly GO:0051490 IMP
    nuclear envelope budding GO:0140591 IMP
Subcellular Localization
    dynactin complex GO:0005869 ISS
    adherens junction GO:0005912 IDA
    F-actin capping protein complex GO:0008290 IDA
    WASH complex GO:0071203 ISS
 Experiment description of studies that identified cpb in exosomes
1
Experiment ID 202
MISEV standards
IEM
Biophysical techniques
TSG10|RAB35|FLOT2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors "Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP."
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for cpb
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Ndg  
Two-hybrid Drosophila melanogaster
2 CG17744  
Two-hybrid Drosophila melanogaster
3 CG1847  
Two-hybrid Drosophila melanogaster
4 cpa 37387
Two-hybrid Drosophila melanogaster
Affinity Capture-MS Drosophila melanogaster
5 Aats-lys  
Two-hybrid Drosophila melanogaster
6 Rpd3  
Two-hybrid Drosophila melanogaster
7 bsf  
Two-hybrid Drosophila melanogaster
8 Ant2  
Two-hybrid Drosophila melanogaster
9 Dmn  
Affinity Capture-MS Drosophila melanogaster
10 sesB  
Two-hybrid Drosophila melanogaster
11 Arpc3A  
Affinity Capture-MS Drosophila melanogaster
12 CG5537  
Two-hybrid Drosophila melanogaster
13 Arpc5  
Affinity Capture-MS Drosophila melanogaster
14 cer  
Two-hybrid Drosophila melanogaster
15 CG18748  
Affinity Capture-MS Drosophila melanogaster
16 Cp16  
Two-hybrid Drosophila melanogaster
17 La  
Two-hybrid Drosophila melanogaster
18 RpS18 37292
Two-hybrid Drosophila melanogaster
19 CG8177  
Two-hybrid Drosophila melanogaster
20 Swip-1 35158
Affinity Capture-MS Drosophila melanogaster
21 CG1399  
Affinity Capture-MS Drosophila melanogaster
22 CG7049  
Affinity Capture-MS Drosophila melanogaster
23 Hsp26  
Two-hybrid Drosophila melanogaster
24 RpLP1  
Two-hybrid Drosophila melanogaster
25 Act57B  
Affinity Capture-MS Drosophila melanogaster
26 Sirt6  
Two-hybrid Drosophila melanogaster
27 CG8578  
Affinity Capture-MS Drosophila melanogaster
28 Arpc4  
Affinity Capture-MS Drosophila melanogaster
29 didum  
Affinity Capture-MS Drosophila melanogaster
30 RpL12  
Two-hybrid Drosophila melanogaster
31 Arp2  
Affinity Capture-MS Drosophila melanogaster
32 CG12042  
Affinity Capture-MS Drosophila melanogaster
33 Arpc1  
Affinity Capture-MS Drosophila melanogaster
34 Hsp83  
Two-hybrid Drosophila melanogaster
35 porin  
Two-hybrid Drosophila melanogaster
36 Arpc2  
Affinity Capture-MS Drosophila melanogaster
37 RecQ5  
Two-hybrid Drosophila melanogaster
38 Arp10  
Affinity Capture-MS Drosophila melanogaster
39 GlyP  
Two-hybrid Drosophila melanogaster
40 Moe  
Two-hybrid Drosophila melanogaster
41 mRpS5  
Two-hybrid Drosophila melanogaster
42 Arp3  
Affinity Capture-MS Drosophila melanogaster
43 RpL23  
Two-hybrid Drosophila melanogaster
44 Ercc1  
Two-hybrid Drosophila melanogaster
45 spag  
Two-hybrid Drosophila melanogaster
46 Cp15  
Two-hybrid Drosophila melanogaster
View the network image/svg+xml



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