Gene description for Vha26
Gene name Vacuolar H[+]-ATPase 26kD subunit
Gene symbol Vha26
Other names/aliases ATP6V1E1
BcDNA.GH03683
BcDNA:GH03683
CG1088
DmelCG1088
VhaE
anon-83Bb
chr3R:1419698..1419836
vATPase
vha26
Species Drosophila melanogaster
 Database cross references - Vha26
ExoCarta ExoCarta_40679
Entrez Gene 40679
UniProt P54611  
 Vha26 identified in exosomes derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for Vha26
Molecular Function
    proton-transporting ATPase activity, rotational mechanism GO:0046961 IEA
Biological Process
    ATP hydrolysis coupled proton transport GO:0015991 IEA
    proton transport GO:0015992 NAS
Subcellular Localization
    plasma membrane proton-transporting V-type ATPase complex GO:0033181 IMP
    vacuolar proton-transporting V-type ATPase, V1 domain GO:0000221 NAS
    plasma membrane GO:0005886 IDA
 Experiment description of studies that identified Vha26 in exosomes
1
Experiment ID 202
ISEV standards
IEM
EV Biophysical techniques
TSG10|RAB35
EV Cytosolic markers
FLOT2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP.
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Vha26
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Vha26 is involved
PathwayEvidenceSource
Insulin receptor recycling IEA Reactome
Transferrin endocytosis and recycling IEA Reactome





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