Gene description for Tctp
Gene name Translationally controlled tumor protein ortholog (H. sapiens)
Gene symbol Tctp
Other names/aliases CG4800
DmelCG4800
TCTP
dTCTP
Species Drosophila melanogaster
 Database cross references - Tctp
ExoCarta ExoCarta_41341
Entrez Gene 41341
UniProt Q9VGS2  
 Tctp identified in exosomes derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for Tctp
Molecular Function
    calcium ion binding GO:0005509 ISS
    Ras guanyl-nucleotide exchange factor activity GO:0005088 IDA
    guanyl-nucleotide exchange factor activity GO:0005085 IDA
Biological Process
    mitotic G2 DNA damage checkpoint GO:0007095 IMP
    double-strand break repair GO:0006302 IMP
    positive regulation of histone phosphorylation GO:0033129 IDA
    cellular response to gamma radiation GO:0071480 IMP
    intra-S DNA damage checkpoint GO:0031573 IMP
    positive regulation of cell size GO:0045793 IMP
    positive regulation of multicellular organism growth GO:0040018 IMP
Subcellular Localization
    polytene chromosome GO:0005700 IDA
    plasma membrane GO:0005886 IDA
    cytoplasm GO:0005737 NAS
    nucleus GO:0005634 IDA
    tubulin complex GO:0045298 ISS
 Experiment description of studies that identified Tctp in exosomes
1
Experiment ID 202
ISEV standards
IEM
EV Biophysical techniques
TSG10|RAB35
EV Cytosolic markers
FLOT2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP.
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Tctp
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Tctp is involved
No pathways found





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