Gene description for Tctp
Gene name Translationally controlled tumor protein ortholog (H. sapiens)
Gene symbol Tctp
Other names/aliases CG4800
DmelCG4800
TCTP
dTCTP
Species Drosophila melanogaster
 Database cross references - Tctp
ExoCarta ExoCarta_41341
Vesiclepedia VP_41341
Entrez Gene 41341
UniProt Q9VGS2  
 Tctp identified in exosomes derived from the following tissue/cell type
Drosophila S2 cells 23035643    
 Gene ontology annotations for Tctp
Molecular Function
    guanyl-nucleotide exchange factor activity GO:0005085 IDA
    protein kinase activator activity GO:0030295 IDA
Biological Process
    double-strand break repair GO:0006302 IMP
    mitotic G2 DNA damage checkpoint signaling GO:0007095 IMP
    mitotic intra-S DNA damage checkpoint signaling GO:0031573 IMP
    positive regulation of multicellular organism growth GO:0040018 IMP
    positive regulation of cell size GO:0045793 IMP
    cellular response to gamma radiation GO:0071480 IMP
    regulation of stem cell differentiation GO:2000736 IMP
Subcellular Localization
    nucleus GO:0005634 IDA
    polytene chromosome GO:0005700 IDA
 Experiment description of studies that identified Tctp in exosomes
1
Experiment ID 202
MISEV standards
IEM
Biophysical techniques
TSG10|RAB35|FLOT2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23035643    
Organism Drosophila melanogaster
Experiment description Drosophila S2 cells secrete Wingless on exosome-like vesicles but the Wingless gradient forms independently of exosomes.
Authors "Beckett K, Monier S, Palmer L, Alexandre C, Green H, Bonneil E, Raposo G, Thibault P, Borgne RL, Vincent JP."
Journal name Traffic
Publication year 2012
Sample Drosophila S2 cells
Sample name Normal-Drosophila S2 tub-Wg
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for Tctp
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CG14715  
Affinity Capture-MS Drosophila melanogaster
2 awd  
Affinity Capture-MS Drosophila melanogaster
3 2mit  
Two-hybrid Drosophila melanogaster
4 CG10638  
Affinity Capture-MS Drosophila melanogaster
5 Msp300  
Two-hybrid Drosophila melanogaster
6 Vha26 40679
Two-hybrid Drosophila melanogaster
7 Df31  
Affinity Capture-MS Drosophila melanogaster
8 ctp  
Two-hybrid Drosophila melanogaster
9 rdx  
Two-hybrid Drosophila melanogaster
10 Nlp  
Affinity Capture-MS Drosophila melanogaster
11 Crc  
Affinity Capture-MS Drosophila melanogaster
12 Chd64  
Affinity Capture-MS Drosophila melanogaster
13 regucalcin  
Affinity Capture-MS Drosophila melanogaster
14 CG8173  
Two-hybrid Drosophila melanogaster
15 Eaf  
Two-hybrid Drosophila melanogaster
16 CG34380  
Two-hybrid Drosophila melanogaster
17 Snx6  
Two-hybrid Drosophila melanogaster
18 Su(var)3-9  
Two-hybrid Drosophila melanogaster
19 Eno  
Affinity Capture-MS Drosophila melanogaster
20 Sap47  
Two-hybrid Drosophila melanogaster
21 CG14410  
Two-hybrid Drosophila melanogaster
22 CG9986  
Two-hybrid Drosophila melanogaster
23 CTPsyn  
Proximity Label-MS Drosophila melanogaster
24 cib 31359
Affinity Capture-MS Drosophila melanogaster
25 Pdi  
Affinity Capture-MS Drosophila melanogaster
26 Sh3beta 38820
Affinity Capture-MS Drosophila melanogaster
27 chic  
Affinity Capture-MS Drosophila melanogaster
28 C1GalTA  
Two-hybrid Drosophila melanogaster
29 AnxB10  
Affinity Capture-MS Drosophila melanogaster
30 PHGPx 38413
Affinity Capture-MS Drosophila melanogaster
View the network image/svg+xml
 Pathways in which Tctp is involved
No pathways found





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