Gene description for PAPPA
Gene name pregnancy-associated plasma protein A, pappalysin 1
Gene symbol PAPPA
Other names/aliases ASBABP2
DIPLA1
IGFBP-4ase
PAPA
PAPP-A
PAPPA1
Species Homo sapiens
 Database cross references - PAPPA
ExoCarta ExoCarta_5069
Entrez Gene 5069
HGNC 8602
MIM 176385
UniProt Q13219  
 PAPPA identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for PAPPA
Molecular Function
    metallopeptidase activity GO:0008237 NAS
    metalloendopeptidase activity GO:0004222 IEA
    zinc ion binding GO:0008270 NAS
Biological Process
    cellular protein metabolic process GO:0044267 TAS
    proteolysis GO:0006508 IEA
    female pregnancy GO:0007565 NAS
    cell differentiation GO:0030154 IEA
Subcellular Localization
    membrane GO:0016020 IEA
    extracellular region GO:0005576 TAS
 Experiment description of studies that identified PAPPA in exosomes
1
Experiment ID 126
ISEV standards
✘ EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for PAPPA
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PLG 5340
Biochemical Activity Homo sapiens
2 C3 718
Invitro Homo sapiens
3 PRG2  
Invitro Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
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