Gene description for TRPV2
Gene name transient receptor potential cation channel, subfamily V, member 2
Gene symbol TRPV2
Other names/aliases VRL
VRL-1
VRL1
Species Homo sapiens
 Database cross references - TRPV2
ExoCarta ExoCarta_51393
Entrez Gene 51393
HGNC 18082
MIM 606676
UniProt Q9Y5S1  
 TRPV2 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for TRPV2
Molecular Function
    ion channel activity GO:0005216 TAS
    ion transmembrane transporter activity GO:0015075 TAS
    calcium channel activity GO:0005262 IEA
    cation channel activity GO:0005261 IDA
Biological Process
    positive regulation of calcium ion import GO:0090280 IEA
    sensory perception GO:0007600 TAS
    response to temperature stimulus GO:0009266 IDA
    ion transmembrane transport GO:0034220 TAS
    transmembrane transport GO:0055085 TAS
    calcium ion transmembrane transport GO:0070588 TAS
    transport GO:0006810 TAS
    positive regulation of axon extension GO:0045773 IEA
    response to heat GO:0009408 IEA
Subcellular Localization
    cell body GO:0044297 IEA
    integral component of plasma membrane GO:0005887 TAS
    melanosome GO:0042470 IEA
    plasma membrane GO:0005886 TAS
    axonal growth cone GO:0044295 IEA
    cell surface GO:0009986 IEA
    endomembrane system GO:0012505 IEA
    growth cone membrane GO:0032584 IEA
 Experiment description of studies that identified TRPV2 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for TRPV2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which TRPV2 is involved
PathwayEvidenceSource
TRP channels TAS Reactome





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