Gene description for SIRPG
Gene name signal-regulatory protein gamma
Gene symbol SIRPG
Other names/aliases CD172g
SIRP-B2
SIRPB2
SIRPgamma
bA77C3.1
Species Homo sapiens
 Database cross references - SIRPG
ExoCarta ExoCarta_55423
Vesiclepedia VP_55423
Entrez Gene 55423
HGNC 15757
MIM 605466
UniProt Q9P1W8  
 SIRPG identified in exosomes derived from the following tissue/cell type
Retinal pigment epithelial cells 35333565    
Retinal pigment epithelial cells 35333565    
 Gene ontology annotations for SIRPG
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    cell adhesion GO:0007155 IEA
    cell-cell signaling GO:0007267 TAS
    positive regulation of cell population proliferation GO:0008284 IDA
    negative regulation of cell population proliferation GO:0008285 TAS
    positive regulation of cell-cell adhesion GO:0022409 IDA
    intracellular signal transduction GO:0035556 TAS
    positive regulation of phagocytosis GO:0050766 IBA
    positive regulation of T cell activation GO:0050870 IBA
    positive regulation of T cell activation GO:0050870 IDA
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 TAS
    membrane GO:0016020 IDA
 Experiment description of studies that identified SIRPG in exosomes
1
Experiment ID 834
MISEV standards
✔
EM
Biophysical techniques
✔
LAMP2|CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 835
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|FLOT1|ITGA2B|ICAM1|CD9|CD151|TFRC|RAB5A|GAPDH|AQP1|TSG101
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35333565    
Organism Homo sapiens
Experiment description LAMP2A regulates the loading of proteins into exosomes
Authors "Ferreira JV, da Rosa Soares A, Ramalho J, Máximo Carvalho C, Cardoso MH, Pintado P, Carvalho AS, Beck HC, Matthiesen R, Zuzarte M, Girão H, van Niel G, Pereira P"
Journal name Sci Adv
Publication year 2022
Sample Retinal pigment epithelial cells
Sample name ARPE-19
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for SIRPG
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SPCS2 9789
Affinity Capture-MS Homo sapiens
2 SIRPA 140885
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 LTF 4057
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here