Gene description for LMBRD1
Gene name LMBR1 domain containing 1
Gene symbol LMBRD1
Other names/aliases C6orf209
LMBD1
MAHCF
NESI
Species Homo sapiens
 Database cross references - LMBRD1
ExoCarta ExoCarta_55788
Entrez Gene 55788
HGNC 23038
MIM 612625
UniProt Q9NUN5  
 LMBRD1 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
 Gene ontology annotations for LMBRD1
Molecular Function
    insulin receptor binding GO:0005158 IEA
    cobalamin binding GO:0031419 IEA
Biological Process
    cobalamin metabolic process GO:0009235 TAS
    small molecule metabolic process GO:0044281 TAS
    negative regulation of protein kinase B signaling GO:0051898 IEA
    viral process GO:0016032 IEA
    negative regulation of glucose import GO:0046325 IEA
    negative regulation of insulin receptor signaling pathway GO:0046627 IEA
    vitamin metabolic process GO:0006766 TAS
    insulin receptor internalization GO:0038016 IEA
    water-soluble vitamin metabolic process GO:0006767 TAS
Subcellular Localization
    membrane GO:0016020 IDA
    integral component of membrane GO:0016021 IEA
    plasma membrane GO:0005886 IEA
    lysosomal membrane GO:0005765 TAS
    clathrin-coated endocytic vesicle GO:0045334 IEA
 Experiment description of studies that identified LMBRD1 in exosomes
1
Experiment ID 207
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|HSP70
EV Cytosolic markers
✔
FLOT1
EV Membrane markers
✔
VDAC
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ.
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 208
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|HSP70
EV Cytosolic markers
✔
FLOT1
EV Membrane markers
✔
VDAC
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ.
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 209
ISEV standards
✘ EV Biophysical techniques
✔
TSG101|HSP70
EV Cytosolic markers
✔
FLOT1
EV Membrane markers
✔
VDAC
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ.
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for LMBRD1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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