Gene description for WWC3
Gene name WWC family member 3
Gene symbol WWC3
Other names/aliases BM042
Species Homo sapiens
 Database cross references - WWC3
ExoCarta ExoCarta_55841
Entrez Gene 55841
HGNC 29237
UniProt Q9ULE0  
 WWC3 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for WWC3
Molecular Function
    protein complex scaffold GO:0032947 IDA
    kinase binding GO:0019900 IPI
Biological Process
    negative regulation of organ growth GO:0046621 IMP
    negative regulation of hippo signaling GO:0035331 IDA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IDA
Subcellular Localization
    cytosol GO:0005829 IDA
 Experiment description of studies that identified WWC3 in exosomes
1
Experiment ID 235
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for WWC3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which WWC3 is involved
No pathways found





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