Gene description for SLC50A1
Gene name solute carrier family 50 (sugar efflux transporter), member 1
Gene symbol SLC50A1
Other names/aliases HsSWEET1
RAG1AP1
SCP
SWEET1
slv
Species Homo sapiens
 Database cross references - SLC50A1
ExoCarta ExoCarta_55974
Vesiclepedia VP_55974
Entrez Gene 55974
HGNC 30657
MIM 613683
UniProt Q9BRV3  
 SLC50A1 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for SLC50A1
Molecular Function
    protein binding GO:0005515 IPI
    glucoside transmembrane transporter activity GO:0042947 IDA
    sugar transmembrane transporter activity GO:0051119 IBA
    sugar transmembrane transporter activity GO:0051119 TAS
Biological Process
    carbohydrate transport GO:0008643 IBA
    hexose transmembrane transport GO:0008645 TAS
    glucoside transport GO:0042946 IEA
Subcellular Localization
    Golgi membrane GO:0000139 IEA
    Golgi apparatus GO:0005794 IDA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    endomembrane system GO:0012505 ISS
    membrane GO:0016020 IBA
 Experiment description of studies that identified SLC50A1 in exosomes
1
Experiment ID 237
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for SLC50A1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CREB3  
Two-hybrid Homo sapiens
2 SRSF1 6426
Affinity Capture-MS Homo sapiens
3 CDC25C  
Affinity Capture-MS Homo sapiens
4 SDCBP 6386
Two-hybrid Homo sapiens
5 SMG9 56006
Two-hybrid Homo sapiens
6 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
7 MTERF3  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which SLC50A1 is involved
PathwayEvidenceSource
Cellular hexose transport TAS Reactome
SLC-mediated transmembrane transport TAS Reactome
Transport of small molecules TAS Reactome





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